ADH (Vasopressin) and Natriuretic Peptides – Regulation of Ambulatory Blood Pressure (ABP)

by Thad Wilson, PhD

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    Antidiuretic Hormone or Arginine Vasopressin. This molecule will also increase blood pressure and it does it through another mechanism. Angiotensin II directly stimulates its release. Hyperosmolality which means a high plasma osmolality will also stimulate its increase. If there is sympathetic stimulation that will also stimulate arginine vasopressin antidiuretic hormone to be released. It is released from the posterior pituitary and will bind to a couple of systemic receptors. V1 receptors are located on blood vessels and that will cause vasoconstriction. Remember vasoconstriction decreases tubuloluminal diameter which increases resistance which then increases arterial blood pressure. V2 receptors are located in the collecting tubules and this helps with water or fluid reabsorption. This increases blood volume and it is blood volume then increasing preload, increasing cardiac output will then increase arterial blood pressure. So another way to respond to a decrease in arterial blood pressure is by releasing antidiuretic hormone or arginine vasopressin. Another neurohumoral factor is natriuretic peptides. Natriuretic peptides are going to work in opposition of some of the other things like the renin-angiotensin-aldosterone system that has been discussed previously. Atrial natriuretic peptide has its own items or stimulatory factors that allow it to be released. They respond to atrial distension which means how much stretch is done to the atrium, that's the right or the left atrium. Sympathetic stimulation also stimulates its release. Angiotensin II and endothelin. All are stimulatory factors for ANP. Probably the most important of these though is atrial distension. So if you have a distended atrium, it means that too much fluid went into it. It stretched it too much. So how are you going to respond to too much stretch? Well, one reason could be there's too much blood volume in the system. So maybe you want to get rid of blood volume...

    About the Lecture

    The lecture ADH (Vasopressin) and Natriuretic Peptides – Regulation of Ambulatory Blood Pressure (ABP) by Thad Wilson, PhD is from the course Vascular Physiology.

    Included Quiz Questions

    1. Sympathetic stimulation
    2. Aortic stretch
    3. Aldosterone
    4. Anti-diuretic hormone
    1. Collecting tubules
    2. Glomerulus
    3. Proximal convoluted tubules
    4. Loop of Henle
    5. Bowman’s capsule
    1. Increased blood volume
    2. Decreased preload
    3. Decreased afterload
    4. Decreased cardiac output
    5. Decreased blood volume

    Author of lecture ADH (Vasopressin) and Natriuretic Peptides – Regulation of Ambulatory Blood Pressure (ABP)

     Thad Wilson, PhD

    Thad Wilson, PhD

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