Leukemia: Acute Myeloid Leukemia (AML) – White Blood Cell Pathology

by Carlo Raj, MD

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    Our topic is AML, acute myelogenous leukemia. Our focus here will be, in fact, M3. You must memorize if you haven't already for M3. Translocation 15;17. And why that’s important to you is the fact that you can actually treat a patient with AML, M3 type with a drug vitamin actually. A vitamin derivative known as ATRA, all trans retinoic acid. How is it possible that you can specifically treat M3 with ATRA and really none of the others? The translocation 15;17 gives rise to in M3 a retinoic acid receptor alpha, RARA. Excuse me? RARA. Receptor for vitamin A alpha is what that is. Retinoic acid receptor alpha. Excuse me, sometimes you got to laugh, otherwise it makes it quite difficult. 8;21 is another one. This is M2. Please know this as being myeloblastic if I were you, myeloblastic. Promyelocytic is M3. Myeloblastic is M2. Translocation number is 8;21. Genetic abnormalities with AML lead to defects in stem cell maturation. And by definition, what kind of blasts are you going to find or what percentage of blasts are you going to find in your bone marrow here? Greater than 20% blasts by definition, by definition. A quick note about myelodysplastic syndrome and why is it even here? Myelodysplastic syndrome, to make your life easier, you need to think of this being preleukemic. The method by which your patient most likely develop myelodysplastic syndrome was the fact the patient was actually receiving treatment. While receiving treatment, unfortunately, the patient starts developing myelodysplastic syndrome. We call this preleukemic. Preleukemic specifically for AML. So that means that this patient is going to have a blast count above 10, but less than 20, in the middle. Let’s take a look. May precede AML, myelodysplastic syndrome. Where are you? In the bone marrow. Myelodysplastic...

    About the Lecture

    The lecture Leukemia: Acute Myeloid Leukemia (AML) – White Blood Cell Pathology by Carlo Raj, MD is from the course Leukemia – White Blood Cell Pathology (WBC).

    Included Quiz Questions

    1. t(15;17)
    2. 11q23 abnormalities
    3. t(14;18)(q32;q21)
    4. t(11;14)(q13;q32)
    5. t(8;21)
    1. t(8;21)
    2. t(14;18)
    3. t(9;22)
    4. t(11;14)
    5. t(15;17)
    1. Greater than 10%
    2. Greater than 20%
    3. Less than 5%
    4. Greater than 25%
    5. Less than 10%
    1. Auer rods
    2. Bence Jones protein
    3. Cabot rings
    4. Bart hemoglobin
    5. Balbiani rings
    1. … acute erythroid leukemia
    2. … AML with maturation
    3. …acute megakaryocytic leukemia
    4. …acute promyelocytic leukemia
    5. … acute myelomonocytic leukemia
    1. FAB subtype M3
    2. FAB subtype M5
    3. FAB subtype M7
    4. FAB subtype M4
    5. FAB subtype M6
    1. Acute promyelocytic leukemia
    2. Undifferentiated acute myeloblastic leukemia
    3. Acute monocytic leukemia
    4. Acute erythroid leukemia
    5. Acute myeloblastic leukemia with minimal maturation

    Author of lecture Leukemia: Acute Myeloid Leukemia (AML) – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD

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    Great cancer understandings
    By Breeana M. on 26. April 2017 for Leukemia: Acute Myeloid Leukemia (AML) – White Blood Cell Pathology

    The lectures were great. It clearly explains the information and the pictures/presentation went well with him. It was easy to follow along not to fast were you get lost but not to slow were you are falling asleep