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Acute Interstitial Nephritis

by Mohammad Hajighasemi-Ossareh, MD, MBA

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    00:01 An important topic is drug induced interstitial nephritis or also called acute interstitial nephritis or more commonly heard on the ward as AIN.

    00:11 Now, this is when you have acute inflammation of the renal interstitium due to exposure to toxins or drugs.

    00:19 Signs and symptoms include a fever, rash and you see an Ophelia and 20 to 35% of patients, only about 10% of patients exhibit all three of these It should also be noted that there's no standard time frame for the onset of medication induced acute interstitial nephritis to take place.

    00:37 So clinicians must be constantly on the lookout.

    00:39 Now, how do you remember the causes of interstitial nephritis? Well, we used the mnemonic, P SQUARE.

    00:46 The first is P and these include penicillin, the antibiotic; phenytoin, the antiepileptic; and proton pump inhibitors like pantoprazole.

    00:56 Now, then you have S and here we have sulfa drugs such as Bactrim.

    01:01 Q, quinolone and quinidine and U are drugs that make you urinate such as Lasix or hydrochlorothiazide.

    01:01 Q, quinolone and quinidine and U are drugs that make you urinate such as Lasix or hydrochlorothiazide.

    01:10 A for allopurinol and Advil, ibuprofen or NSAIDs here, and then R is for rifampin which recall will rev up cytochrome P450 and E is that this will cause an eosinophilic cast, a very high yield point to remember.

    01:28 is that this will cause an eosinophilic cast, a very high yield point to remember.


    About the Lecture

    The lecture Acute Interstitial Nephritis by Mohammad Hajighasemi-Ossareh, MD, MBA is from the course Tubulointerstitial Diseases.


    Included Quiz Questions

    1. Eosinophilic casts
    2. Granular casts
    3. Hyaline casts
    4. RBC casts
    5. Tubular casts

    Author of lecture Acute Interstitial Nephritis

     Mohammad Hajighasemi-Ossareh, MD, MBA

    Mohammad Hajighasemi-Ossareh, MD, MBA


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