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At this point, we're looking at the largest category of anemias and this would be
normocytic. We'll begin our discussion by looking at non-hemolytic anemias with
an MCV between 80-100. Of all of the non-hemolytic anemias, the ones the
students tend to be a little confused with would be acute blood loss. Another reason
for that is because the students feel as though that while the RBCs are being
destroyed because you're losing it and then obviously externally they get destroyed
but understand when you're actually losing it they're not being destroyed on the
way out. So therefore, you still must consider this to be a non-hemolytic and
then the reason that you call this normocytic or refer to it as being normocytic
is because you're losing equal quantity of RBCs and then plasma. So this is whole
blood that you're actually losing and so therefore when you actually conduct a
measurement, you end up finding an MCV between 80-100. So that would be
the trickiest but ones you understand the definition, then we can move forward
and also think as to what you want to do with this patient. Oftentimes they would
be a patient that is feeling hypotensive and so therefore IV fluid is something
that you want to give and with that meaning to say that IV fluids do not contain
RBCs. That is not packed RBCs. Is it? Major cause is trauma obviously if there is
enough blood loss and this discussion with also being your best interest to bring
some of those concepts that we looked at earlier in nephrology and as to what
actually controls volume and also controls your osmolarity and when there is
enough blood loss and volume loss, then the priority of the body is to then address
the volume sometimes at the expense of your osmolarity and that discussion
we have had prior. Now with anemia, what else might then cause acute blood
loss? Well, GI bleeding. If there is a bleeding ulcer severe enough or secondary
to poor hypertension, if there is esophageal varices that at some point extremely
dangerous because you're worried about rupture and bleeding and diverticuli and by
that at some point, remember one of the common causes of painless rectal bleeding
is diverticulosis. And if there is enough blood loss, then your patient is going to be in
a state of normocytic, non-hemolytic anemia because the blood is being evacuated
from the body. Now, there are 2 ways that we can do this. We can leave it for
physiology naturally for the plasma to then be replenished or more likely the
scenario is going to be with this type of acute blood loss especially secondary to
trauma the patient is now given saline and so therefore this replaces the plasma
compartment only. Correct? So if it's only compartment that you're replacing
is the plasma fluid, then obviously here you're going to then reveal the anemia
because you're diluting the RBCs. So at first, the whole blood has been loss but then
once you replenish the plasma, then it's the RBCs that are not there. "Oh, look at
these." The anemia has now been unveiled." I hope that makes sense. Then as far
as the bone marrow is concerned, it takes about well approximately a week,
keep it simple, for it to then respond with reticulocytosis. What does that mean
to you? It means that now the body recognizes "Oh my goodness." The RBCs are
not present and so therefore the bone marrow has to now churn out more RBCs
and as it does so well reticulocytosis. What's reticulocyte? It's an immature RBC
by 24 hours. Okay. Completely different from a previous version where the
progenitor is known as your erythroblast, your normoblast.