2,3 BPG

by Kevin Ahern, PhD

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    Well, it turns out that there’s yet another molecule that plays an important role in the process of release of oxygen. The molecule is what you see on the screen. It’s 2,3 BPG or 2,3 bisphosphoglycerate. This molecule is a byproduct of the process of glycolysis, the breakdown of sugar. And it’s a relatively minor byproduct. It’s not made in the individual reactions of glycolysis, but as a byproduct in the synthesis of one of the molecules. That’s not really important. But what is important is that it’s made at a low level when cells are going through metabolism of glucose. If you’re exercising heavily, like you might be in the race or the marathon run, then you’re more likely be producing more of this 2,3 BPG than if you’re sitting around eating pizza, drinking beer and watching television. Exercising muscle tissues produce acid. They produce carbon dioxide and they produce 2,3 BPG. Now this molecule works in a little bit different way than the other two. It works by binding in the hole of the donut of hemoglobin. So when we look at the structure of hemoglobin, the very center of it, there’s a cavity. There’s nothing in that cavity. And it turns out that’s exactly where 2,3 BPG binds. What 2,3 BPG does is when it binds in that cavity, it converts and stabilizes hemoglobin in T-state. Now the T-state you may remember is the state that does not like to have oxygen. So by 2,3 BPG binding into the whole of the hemoglobin, it’s favoring hemoglobin getting rid of as much oxygen as it can. So here’s a third signal that it’s a rapidly metabolizing cell, that the hemoglobin needs to let go of its oxygen and it does that. If we measure the same curves that...

    About the Lecture

    The lecture 2,3 BPG by Kevin Ahern, PhD is from the course Amino Acid Metabolism.

    Included Quiz Questions

    1. It is produced by rapidly metabolizing tissue.
    2. It binds the heme portion of hemoglobin.
    3. It locks hemoglobin into the R-state.
    4. All of the answers are true.
    5. None of the answers are true.
    1. They absorb oxygen.
    2. They absorb CO2.
    3. They absorb protons.
    4. All of the answers are true.
    5. None of the answers are true.
    1. None of the answers are true.
    2. 2,3 BPG binds myoglobin.
    3. 2,3 BPG levels fall.
    4. High 2,3 BPG levels favor the R-state, so oxygen is retained.
    5. All of the answers are true.
    1. It is higher in the blood of smokers.
    2. It binds to the donut of hemoglobin.
    3. It binds hemoglobin in the same place as carbon dioxide.
    4. All of the answers are true.
    5. None of the answers are true.

    Author of lecture 2,3 BPG

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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