X-linked Inheritance

by Georgina Cornwall, PhD

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    In this lecture, we’ll be exploring X-linked inheritance patterns. Now, I’m sure that we’ve all covered X-linked inheritance patterns. So, I’d like you for a moment to think about, maybe jot down some of the things that you recall about X-linked inheritance. Then we’ll move on into the lecture. This should look pretty familiar. When you consider X-linked inheritance, perhaps you thought about the fact that males have an X and a Y chromosome and that females have two X’s or maybe even red-green color blindness or hemophilia A came to mind. Those are both X-linked disorders. We will certainly consider them in more detail as we go through the lecture. You are right to consider that the X and Y component of a male which brings up the concept of hemizygous, meaning having half of the genetic material for that particular chromosome because we have only one X and the female has two X’s. But because the female has two X’s, there are multiple options for expression. We can have homozygous wild type, meaning the normal type or we could have homozygous for the mutant condition which is truthfully quite rare, especially if both alleles are from the exact same place. We’ll discuss that in a little more detail later. Also, a female could be a carrier. They are heterozygous. They could have it hidden on one X and expressed on the other, although it turns out it’s not quite that simple. We’ll explore some of those situations later. Then finally, you have the option of being compound heterozygote. That is the condition where we have two mutant alleles but they are from a different background. Now, that’s a concept that I introduced in an earlier lecture. So, I just wanted to cover it again. Let’s look at a...

    About the Lecture

    The lecture X-linked Inheritance by Georgina Cornwall, PhD is from the course Single-Gene Disorders.

    Author of lecture X-linked Inheritance

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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