00:00
Now I want to show you some of the
lab tests that might be ordered.
00:03
They'll make sense when you
think about we just reviewed
we're going to have problems
with the liver and the brain,
so doing abnormal liver enzymes,
that that's going
to make sense to us.
00:14
We're going to look at
things like AST and ALT
because we know it's a liver
and brain disorder problem
liver enzymes could be off.
00:24
Obviously.
00:25
We're going to be looking for
elevated levels of copper.
00:28
They'll be in the
blood and the urine.
00:31
But for this one we have
to do a urine 24-hour test.
00:34
Now that gets a little tricky
because everybody's got to work
together for urine 24 hour test
because how that starts is eight
o'clock in the morning the patient voids
and then from then on every year
in has to be kept and collected
in the same container
for a full 24 hours.
00:51
If we miss one you have
to start all over again.
00:56
And that makes a very unhappy team,
all the way around and patient.
01:00
Have to keep that urine
cooled in a bucket.
01:03
It's kind of a hassle
but it gives us really good
information about your patient.
01:08
So we can do abnormal liver
enzymes that make sense
because we know it
involves the liver
we can look for elevated
copper levels that makes sense.
01:16
We're gonna look in
the blood and the urine
because we know that the liver is
supposed to take care of that copper
and make it excretable
in the urine
and if it's not working,
both of those levels will be elevated
and we can do genetic testing,
we can look to see if the
patient has those recessive genes
for Wilson's disease.
01:34
We also watch them
for low blood sugar.
01:37
That's one of the things
that goes along with it.
01:39
Remember if you
have liver problems,
it's not that big a connection
to remember low blood sugar
because we know the liver helps
us maintain a stable blood sugar.
01:49
Now you'll also have lower levels
of, what is that word?
Right.
01:53
Ceruloplasmin.
01:55
That's just a protein that
carries copper through the blood
and these patients will actually
We have lower levels of it.
02:02
Remember it's all
building up in there.
02:04
It's not being transported
to be excreted the
way we want it to
that's why they have lower
levels of ceruloplasmin.
02:13
Now some other test this is when
we're getting really aggressive.
02:16
Now we're going
to say hey we need
we need to figure out how
much damage your organs have
taken from the success copper.
02:24
So we could do an MRI of
the brain or the abdomen.
02:27
Why would we do that?
Because we know Wilson's disease
extra copper, it's going to be loaded
up in the liver and in the brain.
02:36
So that's why an MRI
of the brain or abdomen
would be really
good information.
02:41
We can also get more
invasive with a liver biopsy.
02:43
Now that's not very
comfortable for your patient,
but will actually go in and
take a piece of liver tissue out
and look at it
underneath a microscope,
but that should make sense.
02:55
We know and Wilson's disease
were live copper deposits.
02:59
And so we would look at MRI
of the brain and the liver,
is that will be an abdominal MRI
or might actually take tissue
from the liver and examine it.
03:08
Now here's another
system that we use.
03:10
Again, stop.
03:12
Don't memorize this.
03:13
This is just one
of many examples
that are out there
as a point system
for kind of recognizing
How likely is this patient
to have Wilson's disease.
03:23
You see, you've got two points up
there for Kayser Fleischer Rings.
03:25
Remember what those are?
Cool!
That brown circle
around your eye.
03:30
What kind of mood
systems do they have?
What types of,
do they have a hemolytic anemia?
Is it Coombs negative?
What's their serum
ceruloplasmin level?
What's their liver copper
quantitative measurement?
You see all the
categories we have there.
03:45
You don't need to
memorize these,
but just for fun,
check your learning.
03:50
Think through each
one of those symptoms.
03:52
Remember each one of
those categories in blue.
03:55
Can you see if you can
tie it back to the impact
in Wilson's disease.
03:59
That's a great way
for you to review.