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About the Lecture
The lecture Vulvar Intraepithelial Neoplasia & Extramammary Paget´s Disease by Carlo Raj, MD is from the course Disorders of Vulva, Vagina and Cervix.
Included Quiz Questions
A 40 year old female sex worker is diagnosed with carcinoma of the labia majora. Which of the following is the most likely histopathological appearance of this lesion's biopsy?
- Squamous cell carcinoma
- Melanoma
- Bartholin gland adenocarcinoma
- Basal cell carcinoma
- Rhabdomyosarcoma
What is the main difference between histopathology of VIN and condyloma acuminatum?
- VIN shows koilocytes and dysplasia of the squamous epithelium. Condyloma shows koilocytes and hyperplasia of the squamous epithelium.
- VIN shows squamous cells invading the basal layer. Condyloma shows squamous cells in branching pattern.
- VIN shows adenomatous changes in the epithelium, Condyloma shows only inflammatory changes.
- There is no difference. They can only be differentiated by identifying the viral cause.
- VIN shows koilocytes in multiple layers of squamous epithelium. Condyloma shows koilocytes in only one linear layer of squamous epithelium.
All of the following are true about extra mammary Paget's disease of vulva, except
- It is a subtype of squamous cell carcinoma, and is microscopically indistinguishable from VIN.
- It most commonly occurs in old caucasian females.
- It most commonly arises from, and is confined to the epidermis.
- Histologically, it appears as glandular cells within the squamous epithelium.
- Unrelenting pruritis is a common presenting symptom.
Author of lecture Vulvar Intraepithelial Neoplasia & Extramammary Paget´s Disease
Carlo Raj, MD
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