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VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA)

by Carlo Raj, MD
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    We have a condition called Verner–Morrison Syndrome. It's also a.k.a. Pancreatic cholera and the reason for that you'll see. Symptoms of watery diarrhea, hypokalemia and achlorhydria, that sounds an awful lot like WDHA. So now you have some differentials that you want to keep in mind. Now let me walk you through this. You may or may not have ever heard of Verner–Morrison but you might get an answer choice, if you can quickly rule it out then you're going to choose VIPoma, right? Now if you've forgotten what Verner–Morrison syndrome is and you're going through an answer choice, and you know that your patient has MEN1 Pan–Para–Pit and your patient has WDHA. Watery diarrhea–"WD," "H"– Hypokalemia, "A"– Achlorhydira. Same acronym in both. However if it's MEN1, obviously you are going to choose VIPoma, Vasoactive Intestinal Peptide. Let's talk about Verner–Morrison. Massive stool output. Non–islet cell tumor of pancreas. Do you understand why this statement is put here? I just walked you through VIPoma which is an islet cell tumor of the pancreas, part of MEN1. And when MEN1 is part of the pancreas, here, non–islet cell. The acronym WDHA, always have two differentials in mind. The mediators include VIP, secretin, calcitonin. And treatment is surgery or Octreotide. In layman terms, often known as your pancreatic cholera, watery diarrhea....

    About the Lecture

    The lecture VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA) by Carlo Raj, MD is from the course Small and Large Intestine Diseases.


    Included Quiz Questions

    1. Skipped heart beats
    2. Tetani
    3. Nausea and vomiting
    4. Xanthelasma
    5. Colicky abdominal pain
    1. There is an absence of hydrochloric acid in gastric secretions.
    2. There is an increase of potassium in the blood.
    3. There is constipation initially and eventually causing diarrhea.
    4. There is steatorrhea associated with VIPoma.
    5. Stool culture is often positive for parasites.
    1. Non islet cells
    2. Alpha cells
    3. Beta cells
    4. Delta cells
    5. PP cells
    1. Vasointestinal peptide
    2. Insulin levels
    3. Conjugated bilirubin levels
    4. 5 HIAA
    5. Unconjugated bilirubin levels

    Author of lecture VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA)

     Carlo Raj, MD

    Carlo Raj, MD


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