VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA)

by Carlo Raj, MD

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    00:00 We have condition called Verner-Morrison Syndrome.

    00:03 It´s also a.k.a. pancreatic cholera and the reason for that you´ll see.

    00:08 Symptoms of watery diarrhea, hypokalemia and achlorhydria.

    00:12 That sounds an awful a lot like WDHA.

    00:15 So now you have some differentials you wanna keep in mind.

    00:18 Now, let me walk you through this. You may or may not have ever heard of Verner-Morrison but you might get an answer choice. If you can quickly roll it out then you´re gonna choose the VIPoma, right Now, if you´ve forgotten what Verner-Morrison Syndrome is and you´re going through an answer choice, and you know that your patient has MEN1, Pan, Para, Pit and your patient has WDHA (watery diarrhea, WD; H, hypokalemia; A, achlorhydria) same acronym in both.

    00:51 However, if it´s MEN1 obviously, you´re going to choose, VIPoma (vasoactive intestinal peptide).

    01:01 Let´s talk about Verner-Morrison. Massive stool output, non-islet cell tumor of pancreas.

    01:10 Do you understand why this statement is put here? I just walked you through VIPoma which is an islet cell tumor of the pancreas part of MEN1 and when MEN1 is part of the pancreas. Here, non-islet cell.

    01:25 The acronym, WDHA, always have 2 differentials in mind.

    01:30 The mediators include VIP, secretin, calcitonin and treatment is surgery or octreotide.

    01:38 In layman terms, often known as your pancreatic cholera, watery diarrhea.

    About the Lecture

    The lecture VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA) by Carlo Raj, MD is from the course Small and Large Intestine Diseases: Basic Principles with Carlo Raj.

    Included Quiz Questions

    1. Skipped heartbeats
    2. Tetany
    3. Nausea and vomiting
    4. Xanthelasma
    5. Colicky abdominal pain
    1. Hydrochloric acid is absent from gastric secretions.
    2. Potassium in the blood increases.
    3. Constipation initially occurs, eventually causing diarrhea.
    4. Steatorrhea associated with the condition occurs.
    5. Stool culture is often positive for parasites.
    1. Non-islet cells
    2. Alpha cells
    3. Beta cells
    4. Delta cells
    5. PP cells
    1. Vasoactive intestinal peptide
    2. Insulin levels
    3. Conjugated bilirubin levels
    4. 5-HIAA
    5. Unconjugated bilirubin levels

    Author of lecture VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA)

     Carlo Raj, MD

    Carlo Raj, MD

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