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VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA)
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Slides Small and large bowel.pdf
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Download Lecture Overview
00:00 We have condition called Verner-Morrison Syndrome. 00:03 It´s also a.k.a. pancreatic cholera and the reason for that you´ll see. 00:08 Symptoms of watery diarrhea, hypokalemia and achlorhydria. 00:12 That sounds an awful a lot like WDHA. 00:15 So now you have some differentials you wanna keep in mind. 00:18 Now, let me walk you through this. You may or may not have ever heard of Verner-Morrison but you might get an answer choice. If you can quickly roll it out then you´re gonna choose the VIPoma, right Now, if you´ve forgotten what Verner-Morrison Syndrome is and you´re going through an answer choice, and you know that your patient has MEN1, Pan, Para, Pit and your patient has WDHA (watery diarrhea, WD; H, hypokalemia; A, achlorhydria) same acronym in both. 00:51 However, if it´s MEN1 obviously, you´re going to choose, VIPoma (vasoactive intestinal peptide). 01:01 Let´s talk about Verner-Morrison. Massive stool output, non-islet cell tumor of pancreas. 01:10 Do you understand why this statement is put here? I just walked you through VIPoma which is an islet cell tumor of the pancreas part of MEN1 and when MEN1 is part of the pancreas. Here, non-islet cell. 01:25 The acronym, WDHA, always have 2 differentials in mind. 01:30 The mediators include VIP, secretin, calcitonin and treatment is surgery or octreotide. 01:38 In layman terms, often known as your pancreatic cholera, watery diarrhea.
About the Lecture
The lecture VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA) by Carlo Raj, MD is from the course Small and Large Intestine Diseases: Basic Principles with Carlo Raj.
Included Quiz Questions
Which of the following symptoms is expected due to severe electrolyte abnormalities in pancreatic cholera?
- Skipped heartbeats
- Tetany
- Nausea and vomiting
- Xanthelasma
- Colicky abdominal pain
Which of the following statements regarding VIPoma is TRUE?
- Hydrochloric acid is absent from gastric secretions.
- Potassium in the blood increases.
- Constipation initially occurs, eventually causing diarrhea.
- Steatorrhea associated with the condition occurs.
- Stool culture is often positive for parasites.
From which histological structure of the pancreas does the Verner-Morrison syndrome tumor arise?
- Non-islet cells
- Alpha cells
- Beta cells
- Delta cells
- PP cells
A patient is diagnosed with MEN 1 syndrome. He presents with watery diarrhea, hypokalemia, and achlorhydria. Which of the following substances must be measured?
- Vasoactive intestinal peptide
- Insulin levels
- Conjugated bilirubin levels
- 5-HIAA
- Unconjugated bilirubin levels
Author of lecture VIPoma (Verner-Morrison-Syndrome) or Water Diarrhea Hypokalemia Achlorhydria (WDHA)
Carlo Raj, MD
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