00:01
Under female
reproductive pathology,
let us now take a look
at vaginal disorders.
00:06
Our first topic here
will be vaginal tumor.
00:10
If you take a look at the
histologic picture here,
you can notice that you
find keratin pearls.
00:18
As soon as you hear about keratin
pearls or see keratin pearls,
you can’t see the
intracellular bridges
but they’re called
prickles in pathology.
00:27
The point is we’re talking
about squamous cell cancer.
00:31
It is uncommon.
00:34
The greatest risk factor
here will be that of which
we’ve seen with cervical
and with vulvar
referring to HPV
high-risk strain.
00:44
This will give rise to a squamous
cell cancer of your vagina.
00:48
Rare, but know it.
00:51
Here, we’ll take a look at a vaginal
tumor is of the adenocarcinoma type.
00:55
That in itself is
rather bizarre.
00:57
The reason I say that is
if you remember correctly that the
pH within the vagina is decreased
And the reason for that is
because of the lactobacillus.
01:06
Therefore, creating or sustaining
a squamous type of environment.
01:12
The fact that you find a
glandular type of cancer
within the vagina is rare.
01:17
And secondly, high
on your differential.
01:20
And historically,
you should be thinking
about a mother
who had taken diethylstilbestrol
in which her daughter starts
developing
an adenocarcinoma of the vagina
at the tender age of 15 to 20.
01:32
This is a really young lady
who ends up developing
adenocarcinoma of the vagina,
composed of vacuolated and
glycogen containing cells,
which then describes to
you a glandular cell.
01:50
Another important vaginal
tumor with this condition
is found in girls less
than five years of age.
01:59
If you were to take a look
at the vaginal orifice
in this young
five-year-old girl,
it literally looks like
grape-like clusters.
02:07
We have, technically, an
embryonal rhabdomyosarcoma
in which the marker for
this would be desmin
If you remember correctly,
a rhabdomyosarcoma will
be a skeletal muscle malignancy
commonly found in young girls.
02:27
Sarcoma botryoides,
it is an embryonal
rhabdomyosarcoma.
02:33
Description of this, “bunch of
grapes or cluster of grapes”
upon gross examination.