00:00
I've organized information
about casts.
00:03
Now that you know what they are.
I've organized it in a chart.
00:06
Because I think this is
the simplest way
for you to take this information,
and make it your own.
00:11
So the first column is
the type of cast.
00:13
The second one is
what it's made of?
That means the
predominant cellular elements.
00:18
And the third one is
possible causes.
00:20
So when you look at results
of casts,
and you see the type,
this is a great chart
for you to refer to,
to understand what that means
to your patient.
00:29
So let's start with the
Hyaline cast.
00:32
It's the most common type of cast
it's made of a
solidified mucoprotein
remember that
Tamm-Horsfall protein.
00:37
Normally, in someone's urine
you might see
between zero to five of these
on a low power field.
00:45
So it's predominantly made of
mucoproteins.
00:48
And it could be a sign of
pyelonephritis,
chronic renal disease,
dehydration, or vigorous exercise.
00:56
Okay,
blah, blah, blah.
00:58
I know I've put a list out there
for you.
01:00
And sometimes that's hard
to remember.
01:02
But keep in mind casts are formed
when your inflow is low.
01:06
When that urine is going to be
extra concentrated,
or in an acidic environment.
01:11
So we're talking about
Hyaline cast.
01:13
Why does it make sense that
you'll see it in pyelonephritis,
or renal disease?
Well, those classically
have low renal flow.
01:21
But what about
dehydration and vigorous exercise?
Well, those are acute things.
Those come on in an instant.
01:28
So dehydration is
less intravascular volume,
less stuff flowing through
my kidneys.
01:36
And that's why you're more
likely to develop these casts.
01:39
Vigorous exercise?
Oh, yeah,
that's not a stretch.
01:42
Vigorous exercise could cause
the dehydration.
01:46
So that makes sense.
01:49
Anytime you see a list like this,
don't just let it roll by you.
01:52
Stop. Pause.
01:54
Look for ways that you can
chunk information
to make it make sense.
01:58
So we know this is a
pretty common type of cast
made of mucoproteins.
02:02
And we're going to see it
most likely
with low urine flow,
concentrated urine
or in acidic environment.
02:10
Next up,
let's look at Erythocyte.
02:12
So these types of casts
are made up of red blood cells.
02:17
Now, you'll see this
in glomerulonephritis.
02:20
But it might be normal
if the patient plays contact sports.
02:23
Because they can take some
pretty big hits
in the contact sports.
02:27
So if intact erythrocytes
are visualized on
a microscopic exam
of their urinary sediment,
this can help us distinguish between
hematuria and other conditions.
02:39
So microscopic examination
can detect red blood cell cast,
or dysmorphic, right?
Difficultly shaped, oddly shaped,
abnormally shaped
red blood cells.
02:52
Because we divide hematuria into
glomerular, renal,
and neurological ideologies.
02:59
Okay, that's a lot of
vague words.
03:01
So let's go back
and break that own.
03:03
So you get it all in your notes.
03:05
If I see erythrocytes cast that
we would classify as erythrocytes
we know they're made up of
red blood cells.
03:13
Now, this could be a renal problem
or a non-renal problem, right?
So we divided into glomerular,
renal, and urologic ideologies.
03:24
So, if I see red blood cells,
this is going to require
further follow up on my part.
03:31
Next, leukocytes.
Those are white blood cells.
03:34
You're gonna start to see
a common theme here, right?
Pyelonephritis, glomerulonephritis,
interstitial nephritis,
renal inflammatory processes.
03:44
White blood cells are part of the
inflammatory process.
03:48
Look at every word
in that possible causes.
03:51
itis, itis, itis...
03:54
Cool.
03:55
Inflammatory process is
what itis means
because itis means inflammation of
whatever is before that.
04:03
So it would make sense that
leukocyte, or white blood cell casts
are the result of inflammation.
04:11
Now, so get epithelial.
04:13
We're talking about
renal tubule cells.
04:15
So a cast that's an epithelial cast
is made up of renal tubule cells.
04:21
Now this can be the result of acute
remember that's something
that's happening right now.
04:25
Acute tubular necrosis.
04:29
That's no bueno.
04:31
That's not a good thing.
04:32
So the reason
I'm going to see casts,
they're made up
of renal tubule cells
They're going to be called
epithelial
but that could be
acute tubular necrosis.
04:42
It might also be
interstitial nephritis,
eclampsia from seizures,
nephritic syndrome,
and allograft rejection,
heavy metal ingestion
or renal disease.
04:55
Okay, awesome.
04:56
How do we chunk that together?
Well, I want you to first
file away,
if you see epithelial cast
on a microscopic report,
we've got a big problem.
05:06
We have to figure out if it's
something because of an event
that has happened,
and you have that
acute tubular necrosis,
or we've got some other more
complex things going on.
05:16
Honestly, I don't recommend
that you memorize this list.
05:19
I just don't.
05:20
Its too many things.
05:22
This real estate up here
is precious.
05:24
What I want you to know is
if you see a
renal tubules cells, right?
if we see an epithelium cast,
it's a big deal.
05:32
I would remember
acute tubular necrosis,
and a lot of other serious things.
05:38
That's what I would do.
05:40
So I'm gonna ask you,
just write that
write in your note.
05:42
Acute tubular necrosis
and a lot of other serious things.
05:46
Call that good.
05:47
There's only so much information
your brain can memorize.
05:50
And I want you to keep
the most important things
right at the top.
05:54
Okay, let's look at a
granular cast.
05:57
Now, it's made up of
various cell types.
05:59
And this means, I'm sad to say
advanced renal disease.
06:04
It breaks down the cellular cast
and adds plasma proteins
like albumin or immunoglobulin.
06:09
This is a problem.
06:11
So if you have granular casts
made up of various different cells,
hey, that's a difference.
06:17
That's one way you can help
your brain chunk information.
06:20
It is various cell types, right?
It can be kind of
all over the map.
06:24
So what could cause this?
Chronic renal disease.
06:28
This is a sign that this has been
going on for a long time.
06:32
It's not an acute problem.
it's a chronic problem.
06:35
And you have the stasis
or slow down, or stopping
in the nephron.
06:39
You might see it in shorter term
if they have dehydration
or super vigorous exercise.
06:45
But usually, this is a sign
of chronic disease.
06:49
Now, waxy cast.
Just sounds weird to me.
06:53
But again, this is because of
renal stasis
or nephron obstruction.
06:58
Okay, this is a serious problem.
07:00
So it's made up also
of various different cells.
07:03
This tells me there is
very low flow urine
associated with this, right?
So severe and long term
kidney disease
and chronic renal failure.
07:13
You're going to see
waxy cast.
07:15
So when cellular cast
remain in the nephron
for a long time,
because the flow is so low,
before they're actually flushed
into the bladder,
the urine
that's in the bladder.
07:26
The cells may degenerate.
07:28
They become kind of
coarsely granular cast.
07:31
Later, finely granular class
and ultimately a waxy cast.
07:37
So this is really
not a good sign.
07:39
Granular and waxy casts are believed
to come from the renal tubule.
07:45
But either way,
we've got a bigger problem going on.
07:49
Now let's talk about fatty casts.
07:51
Nobody even likes the nam
of that one either.
07:54
But these are hyaline cast
plus fat globules.
07:58
There's no nice way to say that.
08:00
Hyaline cast
and fat globules.
08:03
Now these are formed
when lipid rich epithelial cells
are broken down.
08:08
So that's where
the fat globules come.
08:11
They come from epithelial cells
that are lipid rich.
08:14
Now, this tells me
we got a really high
urinary protein nephrotic syndrome.
08:21
Again, none of these guys
in this part of the chart
are good news for your kidneys.
08:27
Now, these are called broad
because they are
larger than other cast.
08:31
So kinda personal.
It's like the plus size cast, right?
It's a broad because it is larger
than the other cast.
08:39
They're a sign of
end-stage chronic renal disease
and are thought to be formed
in the damaged and dilated tubules.
08:46
That's why they're so much bigger.
08:48
They're called broad,
because that's an indication
that this cast
this mold of the tubules
is showing you
these tubules are so damaged.
08:57
That's why they are
dilated and enlarged.
09:02
Now with crystal casts,
these are present with
urinary solutes,
such as oxalates, urates,
or sulfonamides.
09:10
The word I use there was
urinary solutes,
that means something
that's dissolved in the urine.
09:17
Now oxalates.
09:18
We refer to before
in this video series,
that's oftentimes something
when enough of that gets together,
you can end up with an
excruciating kidney stone.
09:27
So a little bit of crystals,
not that big a deal,
but you are more likely to be
having problems later on.
09:35
So common crystal seen and
even healthy patients include
calcium oxalate,
triple phosphate crystal and
amorphous phosphates.
09:43
So it's not that big a deal
unless they're getting
more and more in number
and they're clumping together.
09:50
Then you're really
gonna care about
but usually crystal casts
are not that big a deal.