00:00
I've used the word casts
so many times.
00:02
It might be starting to sound
weird to you.
00:04
But let me explain
why they're called casts.
00:08
It's because of their shape.
00:10
I want you to think of them as molds
of where they were formed.
00:13
So you know why they're
most likely to form.
00:16
We've got low flow.
00:17
We've talked about those factors.
00:19
But I also want to mention location.
00:22
They're often formed in the
distal convoluted tubules,
or the collecting duct or
the distal nephron.
00:28
Not in the proximal,
or the loop of Henle.
00:32
So keep that in mind,
we're thinking about the location,
it's not in the initial part of it,
it's more toward the end.
00:39
Why that matters is it helps
healthcare providers
diagnose more specifically
what's going on in the kidney.
00:46
So they are called casts
because of their shape.
00:49
So we know they're cylindrical,
because that's the shape
of the tubule,
where they were formed.
00:54
We know they're most likely to form
with urine stasis,
low flow, with a low pH,
more acidic,
and with a higher
urine concentration.
01:04
Let's look at the architecture
of a cast.
01:07
The Matrix of the cast
or the middle of it
is made primarily
of a mucoprotein.
01:13
Sorry, there's no nice way
to say that.
01:15
I mean, just think about it.
01:16
Mucoprotein
doesn't sound really lovely,
but it's called Tamm-Horsfall.
01:22
So that's the name of that
mucoprotein.
01:25
It's secreted by
the renal tubules.
01:28
So remember, things are not
flowing through there very quickly.
01:31
So this normal substances
this normal mucoprotein
that in your tubules,
its hanging out there
for too long,
and the conditions
are just right.
01:40
And that's why these casts
are formed.
01:42
That mucoprotein
is what gets hardened.
01:46
Now complete cast has the matrix,
which is the mucoprotein,
that Tamm-Horsfall protein
that's become solidified.
01:53
But it's got other elements.
01:55
Okay, so let me back up.
01:56
Look at that.
01:57
Watch the technical stuff
I have for you here.
02:00
There's the matrix of the cast.
02:02
What's it made of?
Right. Mucoprotein
or Tamm-Horsfall
if you want to be more complete.
02:08
Now, ready?
Boom!
There you go.
02:11
There's the other elements
that are embedded in the matrix.
02:15
So what is this telling us
about your kidney?
"Hey, things are not moving
through here very well."
So that's why this mucoprotein
that's there normally
is hanging out for so long,
in just the right conditions,
that we end up
with these casts.
02:31
Casts equal mucoprotein
plus other elements
that get embedded in it.
02:36
Ready?
Okay, cool.
02:38
This is why looking at
a microscopic exam,
if you see cast,
we know we have a problem.
02:44
Because the cast generally maintain
the shape and composition
as they pass through
the urinary system.
02:51
That's what helps us identify
specific locations of disease
in the urinary system.
02:56
Okay, so let me give you a picture
that will help you understand
that better.
02:59
Urinary cast can be made up of
we know we got the
mucoprotein, right
and it's hardened.
03:04
But what goes in that?
We can have white blood cells,
red blood cells, kidney cells,
or other substances
such as protein or fat.
03:14
So let's give them a name.
Look at that.
03:16
The predominant cellular elements
determine the type of cast.
03:20
So I have the matrix
and if it's decorated or made up of
mostly white cells,
leukocytes, red cells,
erythrocytes, kidney cells,
epithelial granular,
and Hyaline or fatty.
03:33
So that's how we name
the type of casts.