00:00
Okay, so your hip to the groove
that unstable angina
is a medical emergency.
00:05
We put an ambulance there
riding on two wheels
just to remind you.
00:08
But unstable angina is likely
the result of severe
coronary artery disease
that got complicated by
either of vasospasm or a clot.
00:17
So the arteries were
already narrowed by
severe coronary artery disease,
but we made it worse
when it had a vasospasm
that particular spot
or a clot broke off traveled
right to the narrow part
and that started
to block it off.
00:30
So the clot can be
a rupture of plaque
plus platelet aggregation,
then you end up with a thrombus
which is just another
word for clot.
00:39
So, can you picture
in your mind what
that look like on our drawings?
Good every time you have
your brain pause and recall
you're doing a
great job encoding
and studying with us as you go.
00:50
So we know it's a
medical emergency.
00:52
We put the pictures back
up there for you again
just to remind you
because repetition
is always good
when you're studying.
00:59
Look at the difference
between infarct
and unstable angina
both have atherosclerosis
both have a clot,
But an infarct
that clot has now
blocked off the majority
if not, absolutely all
of the blood supply.
01:14
So how will this be different
than exertional angina?
Well, even at rest
the patient is going to
have angina or chest pain.
01:22
This might be different.
01:23
They may never had
exertional angina before
but all of a sudden
they're feeling it
or their regular angina.
01:30
They're a patient who's
had a history of angina.
01:33
It's much more intense.
01:34
It's very different.
01:36
Now I want to give
you a little side note
sometimes diabetic patients
don't feel or sense
A lot of angina.
01:43
The damage is still going on
and that always made me nervous
when I had a diabetic patient
who told me they had chest pain
that absolutely
got my attention.
01:53
However, just remember
most people will feel it
but some patients
don't or present
and just unusual
symptom presentation
but we're talking about
the classic progression
and what you really
will most often see.
02:08
So you know the difference
between unstable angina
in infarct both how
the arteries look
and what it feels like
but these are clues that
patients need to understand like
hey, this is when you need
to seek medical attention
because this is a
medical emergency.
02:21
So they have chest
pain or angina arrest.
02:24
Maybe they have
exertional angina,
even if they've never
experienced it before
this could be a sign
or their existing angina
that they've experienced
before is much worse.
02:35
Bottom line,
something is different
from their normal.
02:40
I want you to understand
this concept about balance.
02:43
We talked about a lot
in with most diagnosis.
02:46
But in order to not have
chest pain or ischemia,
whatever the heart
needs or demanding
is what the body needs to supply
if for some reason
they are arteries can't
supply the amount of oxygen
that the heart
needs at the moment.
03:02
That's when you have ischemia.
03:04
So our goal in treating this
is to maintain oxygen supply
and decreased oxygen demand.
03:10
That's why when
someone has chest pain
you want them to
lie down and rest.
03:14
You don't want them to keep on
just going on with you activity.
03:17
So we want to decrease
the oxygen demand
which sometimes is enough
to maintain an
adequate oxygen supply
just have to seal
each patient responds.
03:27
So unstable angina
can be result of
severe coronary artery disease
that's complicated by
a vasospasm or a clot,
you got that.
03:35
We know what the
clot can be can be
a rupture of the plaque plus the
plaque and platelet aggregation,
that's what gives us a thrombus,
again just another
name for a clot.
03:45
So if we're going to
prevent infarction,
we've got to look at
what is the big picture?
How do we take care
of these patients?
What we call that
anti ischemic therapy.
03:55
We've got somebody we
know is having chest pain.
03:57
What do we do with a patient
who has unstable angina?
So for those of you in ER
you're going to
become pros at this
because this patient
gets triage or prioritize
right to the top of the list
because with heart
patients time is tissue.
04:14
Now, we're talking about a
much longer-term implication
if we can't rescue
that heart muscle,
so we think about things
for anti ischemic therapy,
like nitroglycerin,
might consider beta blocker
oxygen if the pulse ox is low
and we're going to look at
possibly an ACE inhibitor or an ARB
if they can't handle an ACE
because they have this left
ventricular dysfunction.
04:38
So these are considered
anti ischemic therapy.
04:41
Now I know a lot of you have heard of
MONA, morphine, oxygen, nitro
and aspirin right?
That's going to be in there to
we're just giving you an overview
of some of the treatment plans
and anti ischemic therapy.
04:54
So antiplatelet therapy,
we're going to give an aspirin
and might consider an other
antiplatelet but oftentimes,
it's just a basic aspirin
that a patient is given.
05:04
For anticoagulant therapy,
we're going to look at low
molecular weight heparin,
a direct thrombin inhibitor,
or or even
unfractionated heparin
so that decision will be made
by the healthcare provider.
05:16
Now the worst not
shouldn't say the worst
but the most intense therapy
the one that has the most
significant risk is thrombolytics.
05:25
So after the patient has
gone through diagnostics
and all the contraindications
for risk of hemorrhage
have been ruled out.
05:31
They can't have a recent
trauma, recent surgery,
you know recent GI bleeding
anything that would put this
patient at increased risk
for hemorrhage will be excluded
from receiving a thrombolytic.
05:44
Because thrombolytics (boom)
they are clot busters.
05:48
So since they blow
up clots everywhere,
we want to keep the patient safe
know that this is an
increased risk for hemorrhage.
05:55
So you screen the patient.
05:56
It's also important
that a thrombolytic be
given within a tight window
of time usually within
four hours of onset
because the goal of treating
ischemia, unstable angina
is to prevent infarct.
06:08
If it's greater than four hours
that tissue is likely
not viable now.
06:12
So it's not worth the risk
of restoring perfusion
or blood supply for
tissue that isn't viable.
06:19
Okay so we've kind of coming at
this from a different angle, right?
We're talking here about
antiplatelet therapy,
anticoagulant therapy and
if deemed safe and appropriate
thrombolytic therapy,
and when thrombolytics work,
they are amazing in
what they can do.
06:36
Now let's talk about why
we give beta blockers.
06:39
Well you what a beta
blocker does right?
It's a drug that hits those
beta receptors on the heart.
06:44
We also have receptors
on the lungs,
beta 2 are on the lung,
beta 1 or on the heart.
06:50
But if I give a beta
blocker medication,
it binds with those
receptors on the heart.
06:56
Now the hearts job those
receptors on the heart
is to make it pump
harder and faster,
but if I have a beta
blocker, a medication there
it's not going to
cause that response
it will block that response
of the heart beating
faster and harder.
07:12
Well if I'm in unstable angina,
I'm not getting enough oxygen
for what I'm demanding.
07:18
So if I slow the heart
down make it rest
by not beating as fast
or beating as hard
the hardest not going
to need as much oxygen.
07:27
That's why it's considered
and treating unstable angina.
07:32
Now beta blockers also used
after an MI for the same purpose
because it will decrease
the workload of the heart
and it's been shown
through research
that if a patient post MI
goes home on a beta blocker,
it can reduce their mortality
after having a heart attack.
07:47
So one of the most common drugs
to control ischemia in patients
with stable coronary artery
disease is a beta-blocker.
07:54
It's a long-term effect.
07:57
So if someone goes
home on a beta blocker
the idea is that
we're going to reduce
future attacks of angina
because the heart doesn't
have to work as hard.
08:05
It's slow down and
not pumping is hard
because they've been
given a beta blocker.
08:11
Now oxygen,
we want to watch this carefully
look at their oxygen saturation.
08:16
If it's less than 90 percent
or they're showing us other
signs of respiratory distress,
then we would give oxygen.
08:23
Used to be a given
everyone who rolled in morphine,
oxygen, nitro, aspirin.
08:27
We just gave those immediately
but now we've really found
that it's not helpful to
the patient to have oxygen
unless they need it.
08:35
So that's something
that's relatively new
in the long history of things.
08:39
So keep that in mind.
08:40
We don't just
automatically put oxygen on
we make sure that
saturation is less than 90%
or the patient is in significant
respiratory distress.