Transport and Network of Proteins

by Georgina Cornwall, PhD

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    00:00 We said that microtubules form highway through the cells. So how would I get something made in the cell body of this neuron all the way to the other end of the neuron? Along these highways. But you cannot just crawl along the highway.

    00:14 It turns out that we're learning that there are some really fantastic machinery going on inside the cells too.

    00:19 There are actual molecular motors.

    00:22 Now if you had to make a molecular motor that was going to move along one of these microtubule highways, what sorts of things do you think you would need? You'd first need probably something to carry the stuff, and a place for it to sit, and a way to attach it and then some means of propulsion, right.

    00:43 And so that's exactly what the cell has done to overcome this need to transport things down the microtubules.

    00:51 So here we go. We could have an actual organelle that's being moved.

    00:55 Maybe we're moving mitochondria to the other end of the cell because we need to get some energy going down there.

    01:02 Or maybe we're moving a load of neurotransmitter that's just been made up in the cell body and we need to move that down to the end of the neuron.

    01:10 So we stick it on this little vehicle, which is our cellular motor.

    01:17 And we give it a platform and a means of propulsion. So dynactin are these proteins that allow movement or motor proteins that allow movement pushing the vehicle along that microtubule.

    01:35 Now we need the motor to be stablized on there so we basically give it some wheels with these connector molecules, also of dynein.

    01:51 So that allows us to have this assembly that moves down the microtubule.

    01:59 We have anterograde, moving away, and retrograde, coming back. Transports.

    02:05 So we can take stuff out in the cell and we can bring stuff back.

    02:08 Those molecular motors are slightly different from one another but they essentially work in the same fashion.

    02:16 So the interior network of cytoskeletal elements or proteins that are cytoskeletal elements are actually connected pretty well to an exterior network of proteins that we call the extracellular matrix.

    02:30 The place that they're most tightly connected is at these proteins called integrins.

    02:36 Those are the proteins that anchor many of the cytoskeletal elements to the edge of the cell in order to form more structure for that cell. These proteins transfer across the membrane, they're transmembrane proteins that also have domains on the outside of the cell.

    02:54 And they are associated with other fibers like collagen and elastin and glycoproteins and some other peptidoglycans so that the cell has some sort of protection. Because you'll recall animal cells don't have a cell wall like bacteria do or plant cells do or fungal cells do.

    03:15 And so this extracellular matrix's function is to provide some degree of protection to the cell as well as allow the cells to identify themselves.

    About the Lecture

    The lecture Transport and Network of Proteins by Georgina Cornwall, PhD is from the course Cellular Structure.

    Included Quiz Questions

    1. All of the answers
    2. Actin molecules to contract and pull the assembly along the microtubules
    3. Transport vesicles to carry "goods"
    4. Dynein connector proteins to attach assembly to the microtubules
    5. Dynactin molecular motor to provide propulsion
    1. Dynactin or Dynein activator complex is related to the synthesis of proteins in the extracellular matrix
    2. The cytoskeletal motors in a cell are associated with the transportation and positioning of the membrane bound organelles
    3. The kinesin and dynein motor proteins move along the microtubule tracks by using ATP energy to carry rapid transportation of materials
    4. The rapid transport of mitochondria in the energy deficient areas of a cell, movement of secretory vesicles and axonal transport are good examples of the cytoskeletal mediated transport system
    5. The anterograde transport and retrograde transport systems are associated with outward, and inward flow of materials in the living cells via molecular motor assisted system
    1. Cell identification and protection
    2. Cell division
    3. Transportation of ATP molecules inside the cell
    4. Synthesis of ATP molecules by using sunlight
    5. Assembly of fully functional ribosomes for the translation process

    Author of lecture Transport and Network of Proteins

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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