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Toxic Shock Syndrome and Necrotizing Fasciitis (Flesh-Eating Disease)

by Carlo Raj, MD
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    Our topic here is toxic shock syndrome. Fever. Hypotension, erythema following a streptococcal infection. So now, way back when in pathophysiology in cardiology, we did our shock, shock, shock. So now, we have a septic-type shock. And when we do so, remember your patients with any type of shock, hypovolemic shock, septic shock ,or whatever, or distributive shock, then may result in hypotension due to a superantigen produced by the bacteria. Superantigen produced by the bacteria, most commonly seen in women using tampons. Do not forget this. You see this, I don’t want to say quite commonly, but often enough in which the tampon has been inserted and has been lying around for too long. And unfortunately is introducing a staph infection. No joke. Management: Clindyamycin for the toxin production, vancomycin or nafcillin to kill the staph, make sure that you know this in greater detail. Our topic here is necrotizing fasciitis. A necrotizing fasciitis, what is it? A necrotizing infection of the deep subcutaneous tissue. Look at this, it is not pretty. Type I: Mixed aerobic and anaerobic bacteria, most common in diabetics. And type II: Think of MRSA or group A streptococci. Most common in otherwise healthy patients. Two types of fasciitis. Think of the fascia, the deep portion of your subcutaneous that then undergoes infection. Type I, mixed. Type II, group A streptococci. Management: Surgical debridement of involved fascia. Antibiotics for type I suspected would then be ampicillin-sulbactam. Type II, clindamycin, penicillin G or vancomycin if it’s MRSA. ...

    About the Lecture

    The lecture Toxic Shock Syndrome and Necrotizing Fasciitis (Flesh-Eating Disease) by Carlo Raj, MD is from the course Infectious Skin Diseases. It contains the following chapters:

    • Toxic Shock Syndrome
    • Necrotizing Fasciitis

    Author of lecture Toxic Shock Syndrome and Necrotizing Fasciitis (Flesh-Eating Disease)

     Carlo Raj, MD

    Carlo Raj, MD


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