Subendothelial IC Deposition Viewed With EM

00:00 Corticosteroids and cyclophosphamide.

00:02 Subendothelial deposits is what we're looking at here on electron microscopy.

00:07 Same thing, get in the habit of doing this quickly.

00:10 The more number of times you go to the protocol the better off you’ll be.

00:13 You’ll find your glomerular basement membrane paved road.

00:16 Number two, you look for the foot processes.

00:19 Well, there’s nothing underneath the foot process because this is DPGN.

00:24 Which gives you what? The title of the slide is subendothelial.

00:28 So therefore, you would find this underneath the endothelial cell.

00:31 Thin rim of normal basement membrane, it separates the epithelial side from the obviously the endothelial side.

00:41 Patient has diffused proliferative glomerulonephritis and as we talked about the prototype here, will be SLE.

00:49 If you pay attention, this is your electron microscopy with subendothelial DPGN.

00:55 As you see here on light microscopy, there’s going to be diffused proliferation.

01:01 There is going to be hypercellularity and there’s neutrophils within the mesangium.

01:05 What’s your mesangium? Basically, think of it as being the supportive infrastructure of your glomerulus, which then properly support your glomerular capillaries and all.

01:14 Also, it very much behaves like smooth muscle in which it will contract when need be.