Subendothelial IC Deposition Viewed With EM

by Carlo Raj, MD

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    00:00 Corticosteroids and cyclophosphamide.

    00:02 Subendothelial deposits is what we're looking at here on electron microscopy.

    00:07 Same thing, get in the habit of doing this quickly.

    00:10 The more number of times you go to the protocol the better off you’ll be.

    00:13 You’ll find your glomerular basement membrane paved road.

    00:16 Number two, you look for the foot processes.

    00:18 Well, there’s nothing underneath the foot process because this is DPGN.

    00:24 Which gives you what? The title of the slide is subendothelial.

    00:28 So therefore, you would find this underneath the endothelial cell.

    00:31 Thin rim of normal basement membrane, it separates the epithelial side from the obviously the endothelial side.

    00:41 Patient has diffused proliferative glomerulonephritis and as we talked about the prototype here, will be SLE.

    00:49 If you pay attention, this is your electron microscopy with subendothelial DPGN.

    00:55 As you see here on light microscopy, there’s going to be diffused proliferation.

    01:00 There is going to be hypercellularity and there’s neutrophils within the mesangium.

    01:05 What’s your mesangium? Basically, think of it as being the supportive infrastructure of your glomerulus, which then properly support your glomerular capillaries and all.

    01:14 Also, it very much behaves like smooth muscle in which it will contract when need be.

    About the Lecture

    The lecture Subendothelial IC Deposition Viewed With EM by Carlo Raj, MD is from the course Glomerulonephritis.

    Included Quiz Questions

    1. Subendothelial
    2. Subepithelial
    3. More than one answer is correct
    4. Intermembranous
    5. Mesangial
    1. Both involve activation of the alternative complement pathway
    2. Both involve immune complex deposition
    3. Both show a granular pattern on immunofluorescence
    4. Both may present with between 150 mg–3.5 g/day of protein in the urine
    5. Both present with hematuria
    1. Anti-dsDNA antibodies
    2. Anti-streptokinase
    3. Anti-Ro antibodies
    4. Anti-smith antibodies
    5. Anti-DNase B antibodies
    1. Corticosteroids and cyclophosphamide
    2. Corticosteroids and NSAIDs
    3. Watchful waiting, it usually resolves on its own
    4. ACE inhibitors and cyclophosphamide
    5. Dialysis is the only treatment
    1. It is the only type of glomerulonephritis caused by SLE
    2. It is associated with “wire looping” of capillaries
    3. It often evolves into chronic renal failure
    4. Hypercellularity of the glomerulus is seen on light microscopy
    5. Serum ANA test has a “rim” pattern

    Author of lecture Subendothelial IC Deposition Viewed With EM

     Carlo Raj, MD

    Carlo Raj, MD

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