00:02
So now let's look at
the digestive process
that is carried
out by the stomach.
00:07
Recall that the stomach is
going to break down food
by way of chemical digestion.
00:13
It is also going to
serve as a storage tank
or holding area for food.
00:19
While it is holding food there,
it is also delivering chyme
to the small intestines,
the next organ of
the digestive tract.
00:30
Also, it is going
to denature proteins
by hydrochloric acid
and as well,
it's going to denature proteins
by the enzyme pepsin
which is going to carry
out enzymatic digestion.
00:44
Also, there's a milk
protein on his casein
that is broken down
by renin and infants
but this is only
found in infants
and is not found in
the adult stomach.
00:57
Also lipid-soluble alcohol
as well as aspirin
are actually able to be absorbed
through the lining
of the stomach.
01:06
So we normally don't
consider the stomach
and absorptive digestive organ,
but some chemicals are
able to be absorbed here.
01:17
The only stomach function
that is essential to life
is going to be the secretion
of intrinsic factor.
01:24
This is necessary for
vitamin B12 absorption.
01:29
B12 is absolutely necessary
for our red blood
cells to mature.
01:35
And if you have a lack
of intrinsic factor,
this can lead to a disease
known as pernicious anemia.
01:42
And the way this is treated
is by injecting B12
into the individual.
01:50
So looking at the
gastric secretions,
we find that the gastric
mucosa secretes about 3 liters
of gastric juice a day.
02:00
This is regulated
by neural mechanisms such
as vagus nerve stimulation
which increases secretion
of this gastric mucosa,
and as well sympathetic
stimulation,
which will decrease
the production of
these gastric juices.
02:18
Also, we have hormonal mechanism
such as the hormone gastrin
which is going to
stimulate enzymes
as well as hydrochloric
acid secretion.
02:30
Recall that hydrochloric acid
is what makes the gastric
juice very acidic.
02:37
Also, there are hormones
that are referred to
as gastrin antagonist,
and these are secreted
by the small intestine.
02:48
Secretion of our gastric
juices is going to be regulated
in three phases.
02:54
The first of these phases
is the cephalic phase.
02:58
The cephalic phase happens
prior to food
entering the stomach
and can be triggered by smell,
taste,
or even the sight of food.
03:09
These stimuli are going
to activate neural centers
in the cerebral cortex,
the hypothalamus and
the medulla oblongata
that are going to stimulate
the secretion of gastric juices
as the stomach is
prepared for the food
that will eventually enter.
03:28
The cephalic phase
can be inhibited by
stimuli such as depression.
03:37
The second phase is going
to be the gastric phase.
03:41
And this phase gastric juices
are going to be released.
03:45
This is activated
by stretch receptors
and also chemical stimuli
such as 1 chyme
enters the stomach
and increases the pH slightly
then this chemical stimulus
is going to activate
the secretion of gastrin
which then further
activates the secretion
or release of hydrochloric acid.
04:07
This phase can be inhibited
by excessive acidity
which is a negative
feedback loop
so that the stomach does
not become too acidic.
04:17
And it also can be inhibited
by emotional stress.
04:23
The final phase is
the intestinal phase.
04:26
The intestinal phase involves
partially digested food
that enters into the
small intestines.
04:34
This leads to a brief release
of intestinal gastrin
followed by inhibition
of the release of
gastric juices.
04:44
It is triggered, again,
by the presence of
partiallydigested food
and the duodenum,
which is the first section
of the small intestine.
04:53
Or also the distention
of the duodenum
when the stomach
begins to empty kind
into the duodenal area.
05:03
After a brief gastrin release
by the small intestines,
there's an inhibition
of gastric juices
in the stomach.
05:12
This will then slow
the exit of chyme
from the stomach to the duodenum
so that the duodenum does
not become overwhelmed
with food entering into
the first part of
the small intestine.
05:27
There are four main factors
that are going to
cause this inhibition
of gastric secretions.
05:34
First, the distinction
or stretch of the duodenum
due to entry of kind
is the first thing
that's going to tell our stomach
we need to stop
making gastric juices.
05:46
Next the presence
of this acidic chyme
can be sensed by
receptors and a duodenum
again, sending signals
back to the stomach
to decrease gastric secretions.
06:00
As well, the presence of fatty
chyme also has its effect
and finally the
presence of hypertonic
or very salty kind
can also have the effect of
inhibiting gastric secretions.
06:15
These inhibitory
effects are important
because they protect our
intestines from being overwhelmed
by too much chyme or
by too much acidity.
06:27
This inhibition is going
to be achieved in two ways.
06:30
We have the
enterogastric reflex,
which involves the stretch
receptors in the stomach
the send nerve
impulses to the brain
turning on sympathetic
stimulation in the stomach
and slowing down
gastric motility.
06:46
We also have enterogastrones
which is a hormone
that is secreted
by the duodenum in response
to high fat content,
and also,
slows our gastric motility.
07:01
So speaking of gastric motility
peristaltic waves are going
to move toward the pylorus
or the end of the stomach
at a rate of about
3 times per minute.
07:15
Basic electrical rhythm is set
by enteric pacemaker cells.
07:21
These pacemaker cells are
linked by gap junctions
that caused the entire
muscularis to contract.
07:30
Distension and gastrin release
are going to force the motility
of these peristaltic
waves through the stomach.
07:41
Contractions are most vigorous
and Powerful near the pylorus.
07:47
About 30 milliliters
of chyme is produced
and either delivered
to the intestines
and 3 milliliters spurts
while the rest of
the 27 milliliters
are forced backward
into the stomach.
08:03
Only liquids and small
particles are allowed to pass
through the pyloric valve
without going
through this process.
08:14
The duodenum can
prevent overfilling
by controlling how
much chyme enters
we have duodenal receptors
that respond to both stretch
as well as chemical signals.
08:27
Recall the enterogastric reflex
as well as the
enterogastrone-hormones
inhibit gastric secretions,
which further inhibit
duodenal filling.
08:39
The stomach is able to
empty its entire content
in about four hours.
08:45
However,
if there is a lot of fatty chyme,
so if the content of the chyme
has a large lipid content,
then this time can be
increased to about 6 hours.
08:57
The fastest moving kind
moving from the stomach
into the small intestine
is going to be kind that
is carbohydrate rich.