Steroids and Bile Acids: Receptor-mediated Endocytosis

by Kevin Ahern, PhD

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    00:01 Now, the way the cholesterol actually gets in the cells is interesting.

    00:05 The reason that cholesterol is in the LDLs isn’t to cause heart attacks, but rather to provide a delivery mechanism for cells to get cholesterol.

    00:15 Cells have on their surface a receptor that recognizes and binds the LDLs.

    00:20 If the cell is needing cholesterol, it will grab an LDL out of the blood stream and internalize it in this process that you can see here.

    00:29 So we first have a binding process, followed by endocytosis.

    00:32 And this process is called, receptor-mediated endocytosis, for this purpose.

    00:38 You can see the steps happening inside.

    00:40 There’s actually an unpacking of the LDL that occurs and the goodies inside, including the cholesterol are used by the cell.

    00:47 There’s a recycling that happens where the remnants that aren’t used by the cell are then exported back out of the cell, and at the mean time the cell has gotten cholesterol that it needs for the purposes of making membranes.

    About the Lecture

    The lecture Steroids and Bile Acids: Receptor-mediated Endocytosis by Kevin Ahern, PhD is from the course Lipid Metabolism.

    Included Quiz Questions

    1. To signal the liver for the release of stored fats to the various body parts.
    2. To activate the foam cells of the arteries.
    3. To heal the atherosclerosis plaques.
    4. To activate the immune system to heal the damage caused by reactive oxygen species by their reaction with HDLs.

    Author of lecture Steroids and Bile Acids: Receptor-mediated Endocytosis

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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