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Spleen – Secondary Lymphoid Organs (Nursing)

by Jasmine Clark, PhD

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    00:01 The next lymphoid organ that we're going to discuss is the spleen.

    00:05 The spleen is a very blood-rich organ, about the size of a fist that's located on the left side of the abdominal cavity, just below the stomach.

    00:17 Of the lymphoid organs, the spleen is going to be the largest.

    00:22 It is served by the splenic arteries and vein, which enter and exit at the hilum of the spleen.

    00:32 The spleen functions as a site of lymphocyte proliferation, as well as an immune surveillance, and response point.

    00:42 It's also going to function to clean our blood of aged blood cells as well as platelets.

    00:50 And it also uses macrophages to remove this debris from this area.

    01:00 And so here is a depiction of the location of the spleen in relation to other organs in our abdominal cavity.

    01:10 So the spleen also has a few other additional functions.

    01:14 First, it's going to store the breakdown products of these red blood cells.

    01:19 Remember, it's going to bring in these old aged blood cells.

    01:23 And so it can use some of the stuff that is in there, such as the iron for later reuse.

    01:31 Secondly, the spleen is going to store blood platelets and monocytes that are going to be released into the blood whenever they are needed.

    01:40 Such as when you have an injury, or some type of inflammation or infection.

    01:46 Also, the spleen may serve as a site of fetal erythrocyte production or the production of red blood cells in the fetus.

    01:58 Like the lymph nodes, the spleen is also encased by a fibrous capsule and as another one of our encapsulated lymphoid organs.

    02:08 Also like the lymph node, the spleen has Trabecula from the outside that kind of reach into the inner portion of the spleen Histologically, there are two main components.

    02:22 We have the white pulp, which are going to surround the splenic artery and the inside of the spleen.

    02:29 And this is going to be surrounded by the red pulp.

    02:33 So interestingly, when you look at a section of the spleen, the white pulp kind of looks like a white island in a sea of red.

    02:45 So the white pulp is going to be the site where immune function actually occurs.

    02:51 It contains mostly lymphocytes that are found on reticular fibers, And the white pulp like I said, is going to cluster around the central arteries and appear as islands of white in a sea of red pulp.

    03:07 The red pulp on the other hand is the site where those old blood cells and the bloodborne pathogens are going to be destroyed.

    03:16 This area is very rich in red blood cells as well as macrophages that are going to engulf them.

    03:23 It also contains splenic cords, which is a type of reticular tissue that separates the blood-filled splenic sinusoids, which are very similar to venous sinuses.


    About the Lecture

    The lecture Spleen – Secondary Lymphoid Organs (Nursing) by Jasmine Clark, PhD is from the course Lymphatic System – Physiology (Nursing).


    Included Quiz Questions

    1. Site of lymphocyte proliferation and cleanses the blood
    2. Break down of RBCs for iron and erythrocyte production
    3. Erythrocyte production and iron formation
    4. Platelet storage and fetal break down of RBCs
    1. The white pulp is where immune function occurs and the red pulp is where the old RBCs and pathogens are destroyed
    2. The red pulp is where the immune functions occur and the white pulp is where the old RBCs and pathogens are destroyed
    3. The white pulp is where lymphocytes proliferate and the red pulp is the fluid is transported into the venous system
    4. The red pulp is where lymphocytes proliferate and the white pulp is the fluid is transported into the venous system

    Author of lecture Spleen – Secondary Lymphoid Organs (Nursing)

     Jasmine Clark, PhD

    Jasmine Clark, PhD


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