00:01
Now, another one of the
blockers is a selective
aldosterone antagonist. Remember,
aldosterone
tells my body to hang on to sodium,
and what follows
every time my body hangs on to sodium?
Yeah, water. That's right.
00:19
So what aldosterone tells my kidneys,
"Hey, guys? Hang on to sodium."
When the kidneys reabsorb
or hang on to sodium,
water always follows sodium.
00:30
So, if we've got a selective
aldosterone antagonist,
we're going to have less of that happening.
00:36
We'll have less increased volume,
so we will have less volume.
00:40
Now, these guys are more selective
than spironolactone
because they bind aldosterone receptors
and other hormone receptors.
00:47
So these guys, that's why they're called
selective aldosterone antagonist.
00:53
They're more selective than spironolactone.
00:56
Eplerone only binds to aldosterone
receptors. So,
I don't want to let that go by too quickly.
01:03
Eplerone only binds to aldosterone
receptors.
01:08
It's much more selective than the
spironolactone. So, cool.
01:13
Spironolactone hits aldosterone
receptors and
other hormone receptors but Eplerone,
a selective aldosterone antagonist,
only binds to aldosterone receptors.
So, it's a lot more specific.
01:25
Cool. That's a really good thing because
we'll have less side effects.
01:28
So when you have this aldosterone
receptor blocked,
decreases sodium reabsorption
and therefore,
you have an increased potassium
retention. Remember that,
when I hang on to more sodium,
I lose my potassium.
01:42
But if I'm not hanging on to extra sodium,
I'm going to have an increased potassium.
01:48
So, adverse effects of this?
Risk for hyperkalemia.
01:54
Because I don't have that result
of now I have blocked
that receptor, normally, if
I hang on to sodium, I --
my body gets rid of potassium,
but now I'm blocking those receptors
and that's the reason for
hyperkalemia or high potassium.
02:11
So here's a wrap up of our high blood
pressure categories from normal
all the way through to hypertensive crisis.
02:18
Now, it'd be great if you don't currently
know your blood pressure that
you make sure you do within
the next couple of days.
02:24
Go out and check your blood pressure
and see which of these
categories you fall into.
02:29
And then work your way around your family.
02:31
Give them the excuse that you just need to
practice what you've learned in lab,
but you may make a real impact
on your family's health
if you can monitor their blood pressure,
kind of, undercover.