00:01
Now, another one of the
blockers is a selective
aldosterone antagonist. Remember,
aldosterone
tells my body to hang on to sodium,
and what follows
every time my body hangs on to sodium?
Yeah, water. That's right.
00:19
So what aldosterone tells my kidneys,
"Hey, guys? Hang on to sodium."
When the kidneys reabsorb
or hang on to sodium,
water always follows sodium.
00:30
So, if we've got a selective
aldosterone antagonist,
we're going to have less of that happening.
00:36
We'll have less increased volume,
so we will have less volume.
00:40
Now, these guys are more selective
than spironolactone
because they bind aldosterone receptors
and other hormone receptors.
00:47
So these guys, that's why they're called
selective aldosterone antagonist.
00:53
They're more selective than spironolactone.
00:56
Eplerone only binds to aldosterone
receptors. So,
I don't want to let that go by too quickly.
01:03
Eplerone only binds to aldosterone
receptors.
01:08
It's much more selective than the
spironolactone. So, cool.
01:13
Spironolactone hits aldosterone
receptors and
other hormone receptors but Eplerone,
a selective aldosterone antagonist,
only binds to aldosterone receptors.
So, it's a lot more specific.
01:25
Cool. That's a really good thing because
we'll have less side effects.
01:28
So when you have this aldosterone
receptor blocked,
decreases sodium reabsorption
and therefore,
you have an increased potassium
retention. Remember that,
when I hang on to more sodium,
I lose my potassium.
01:42
But if I'm not hanging on to extra sodium,
I'm going to have an increased potassium.
01:48
So, adverse effects of this?
Risk for hyperkalemia.
01:54
Because I don't have that result
of now I have blocked
that receptor, normally, if
I hang on to sodium, I --
my body gets rid of potassium,
but now I'm blocking those receptors
and that's the reason for
hyperkalemia or high potassium.
02:11
So here's a wrap up of our high blood
pressure categories from normal
all the way through to hypertensive crisis.
02:18
Now, it'd be great if you don't currently
know your blood pressure that
you make sure you do within
the next couple of days.
02:24
Go out and check your blood pressure
and see which of these
categories you fall into.
02:29
And then work your way around your family.
02:31
Give them the excuse that you just need to
practice what you've learned in lab,
but you may make a real impact
on your family's health
if you can monitor their blood pressure,
kind of, undercover.
The lecture Selective Aldosterone Antagonists (Nursing) by Rhonda Lawes, PhD, RN is from the course Cardiovascular Medications (Nursing). It contains the following chapters:
What is the only thing eplerenone binds to?
What is the definition of hyperkalemia?
5 Stars |
|
5 |
4 Stars |
|
0 |
3 Stars |
|
0 |
2 Stars |
|
0 |
1 Star |
|
0 |