Selective Aldosterone Antagonists (Nursing)

by Prof. Lawes

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    00:01 Now, another one of the blockers is a selective aldosterone antagonist. Remember, aldosterone tells my body to hang on to sodium, and what follows every time my body hangs on to sodium? Yeah, water. That's right.

    00:19 So what aldosterone tells my kidneys, "Hey, guys? Hang on to sodium." When the kidneys reabsorb or hang on to sodium, water always follows sodium.

    00:30 So, if we've got a selective aldosterone antagonist, we're going to have less of that happening.

    00:36 We'll have less increased volume, so we will have less volume.

    00:40 Now, these guys are more selective than spironolactone because they bind aldosterone receptors and other hormone receptors.

    00:47 So these guys, that's why they're called selective aldosterone antagonist.

    00:53 They're more selective than spironolactone.

    00:56 Eplerone only binds to aldosterone receptors. So, I don't want to let that go by too quickly.

    01:03 Eplerone only binds to aldosterone receptors.

    01:08 It's much more selective than the spironolactone. So, cool.

    01:13 Spironolactone hits aldosterone receptors and other hormone receptors but Eplerone, a selective aldosterone antagonist, only binds to aldosterone receptors. So, it's a lot more specific.

    01:25 Cool. That's a really good thing because we'll have less side effects.

    01:28 So when you have this aldosterone receptor blocked, decreases sodium reabsorption and therefore, you have an increased potassium retention. Remember that, when I hang on to more sodium, I lose my potassium.

    01:42 But if I'm not hanging on to extra sodium, I'm going to have an increased potassium.

    01:48 So, adverse effects of this? Risk for hyperkalemia.

    01:54 Because I don't have that result of now I have blocked that receptor, normally, if I hang on to sodium, I -- my body gets rid of potassium, but now I'm blocking those receptors and that's the reason for hyperkalemia or high potassium.

    02:11 So here's a wrap up of our high blood pressure categories from normal all the way through to hypertensive crisis.

    02:18 Now, it'd be great if you don't currently know your blood pressure that you make sure you do within the next couple of days.

    02:24 Go out and check your blood pressure and see which of these categories you fall into.

    02:29 And then work your way around your family.

    02:31 Give them the excuse that you just need to practice what you've learned in lab, but you may make a real impact on your family's health if you can monitor their blood pressure, kind of, undercover.

    About the Lecture

    The lecture Selective Aldosterone Antagonists (Nursing) by Prof. Lawes is from the course Cardiovascular Medications (Nursing). It contains the following chapters:

    • Selective Aldosterone Antagonists
    • Wrap-up of Blood Pressure Categories

    Included Quiz Questions

    1. Aldosterone receptors
    2. Sodium receptors
    3. Renin receptors
    4. Angiotensin receptors
    1. High potassium
    2. High ketones
    3. High calcium
    4. High sodium

    Author of lecture Selective Aldosterone Antagonists (Nursing)

     Prof. Lawes

    Prof. Lawes

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