Secretion and Organic Transport in the Proximal Tubule

by Thad Wilson, PhD

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    Hello! We’ll be covering secretion and do a combined review of reabsorption. Let’s review quickly some of the primary renal functions. We had filtration, reabsorption, secretion, and excretion. So today, we’re going to be dealing with the third one - secretion. Secretion is a very important process to be able to move solutes from the blood into the renal tubules so you can get rid of them. In this case, what would you like to get rid of? Oftentimes, it’s things like endogenous or exogenous toxins. So secretion is an important process by which we can get rid of things we don’t want in the blood. So how does this work? Well, secretion is primarily going to be a process to get rid of something rather than to reabsorb it, and this is important. We mainly talked about reabsorption up until this point. So reabsorption is bringing something from the renal tubule back into the blood. Now, we are going to take things from the blood and put it in the renal tubule. This occurs primarily in the late proximal tubule. So the late proximal tubule is the proximal straight tubule. So the proximal convoluted tubule is where a lot of the reabsorption took place and the proximal straight is where secretion will take place. To undergo secretion, we need some very specific transporters. These are organic ion transporters, also abbreviated as OAT and organic cation transporters. These are very specialized transporters. They will probably originally develop simply to get rid of endogenous toxins – things that build up in the body that you want to get rid of. But they also serve another purpose, and that is to get rid of items that you would have taken in or exogenous toxins. It might be a drug. It might be...

    About the Lecture

    The lecture Secretion and Organic Transport in the Proximal Tubule by Thad Wilson, PhD is from the course Renal Physiology.

    Included Quiz Questions

    1. Movement of toxins from blood to tubules
    2. Movement of toxins from renal tubules to blood
    3. Movement of solutes from renal tubules to blood
    4. Movement of unwanted molecules from renal tubules to blood
    5. Movement of wanted molecules from renal tubules to blood
    1. Proximal straight tubule
    2. Proximal convoluted tubule
    3. Bowman's capsule
    4. Thick ascending limb
    5. Thin ascending limb
    1. Blood > OAT1,2,3 > MPR2> Tubular fluid
    2. Tubular fluid > apical membrane> basolateral membrane> interstitial fluid > blood
    3. Tubular fluid > OCTN > OCT > blood
    4. Tubular fluid > MPR2> OAT1,2,3>Blood
    5. Blood > OAT1,2,3 > MPR1> tubular fluid

    Author of lecture Secretion and Organic Transport in the Proximal Tubule

     Thad Wilson, PhD

    Thad Wilson, PhD

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