Now let's look at rhinoviruses, the
cause of the common cold.
And you see another beautiful model
of rhinovirus right in front of you.
It looks so gorgeous, except that,
as we all know, having a cold
makes you miserable.
The rhinovirus is acid labile,
meaning that if it is swallowed
into the stomach,
and it's exposed to
gastric mucosa and gastric acid, then
it will be inactivated, most often.
However, because it is a
it most often is acquired through
the nasal passages
depositing into respiratory
tissue in that way.
There are more than 100
serotypes of rhinovirus.
So even if you are exposed to and infected
with 1 or 2 of those in a season,
there are plenty more options to make
you just as sick the next year.
Transmission, as mentioned,
is via respiratory
that lovely, giving child who sneezes
directly in your face
as you happen to be taking in a breath.
We've all experienced it.
We just know for a fact that in the
incubation period of 7-10 days,
we'll be getting the cold.
Also, fomites, typically,
toys, stethoscopes, beware,
or anything else, horizontal surfaces
that can retain this virus from
the respiratory droplets.
All can transmit the rhinoviruses.
The typical pathogenesis.
Primary infection occurs
in the nasal mucosal,
sometimes even the conjunctiva,
and then we get as the virus creates
its, you know, lytic effects,
we get edema of the subepithelial tissues.
That then drives the onset of
causing the symptoms which we know
of as the common cold.
Primary infection at the same time
for that 1 specific stereotype, 1 out of 100,
will also drive creation of
A, which can be protective,
and it will also drive production
so pro-inflammatory cytokines,
which ultimately will combine to
limit that particular infection.
Now, we all know that some of us
suffer worse than others
with the common cold,
and the thing called a "man cold,"
it's a thing.
Guys just suffer so much worse
Unlike this fabulous patient who
modeled for the camera,
who is simply just blowing her nose, she
doesn't look like death warmed over,
unlike certain men that I know
if they were to get a cold.
However, we all know what the typical
clinical manifestations are:
sneezing, runny nose, headache, sore throat,
feeling -- malaise, and then low grade fever.
And again, incubation period of 7-10 days,
and then treatment or symptomatic course
The common phrase is a cold is 3 days
coming, 3 days with you, 3 days leaving.
All of those describe the entire prodrome
active infection and resolution
of active rhinovirus.