Rhinoviruses – Picornaviruses

by Sean Elliott, MD

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    00:01 Now let's look at rhinoviruses, the cause of the common cold.

    00:04 And you see another beautiful model of rhinovirus right in front of you.

    00:08 It looks so gorgeous, except that, as we all know, having a cold makes you miserable.

    00:14 The rhinovirus is acid labile, meaning that if it is swallowed into the stomach, and it's exposed to gastric mucosa and gastric acid, then it will be inactivated, most often.

    00:28 However, because it is a respiratory transmission, it most often is acquired through the nasal passages depositing into respiratory tissue in that way.

    00:37 There are more than 100 serotypes of rhinovirus.

    00:41 So even if you are exposed to and infected with 1 or 2 of those in a season, there are plenty more options to make you just as sick the next year.

    00:49 Yay, us.

    00:50 Transmission, as mentioned, is via respiratory aerosols, especially that lovely, giving child who sneezes directly in your face as you happen to be taking in a breath.

    01:01 It happens.

    01:01 We've all experienced it.

    01:03 We just know for a fact that in the incubation period of 7-10 days, we'll be getting the cold.

    01:08 Also, fomites, typically, toys, stethoscopes, beware, or anything else, horizontal surfaces that can retain this virus from the respiratory droplets.

    01:20 All can transmit the rhinoviruses.

    01:23 The typical pathogenesis.

    01:25 Primary infection occurs in the nasal mucosal, sometimes even the conjunctiva, and then we get as the virus creates its, you know, lytic effects, we get edema of the subepithelial tissues.

    01:38 That then drives the onset of inflammatory mediators causing the symptoms which we know of as the common cold.

    01:45 Primary infection at the same time for that 1 specific stereotype, 1 out of 100, will also drive creation of secretory immunoglobulin A, which can be protective, and it will also drive production of interferons, so pro-inflammatory cytokines, which ultimately will combine to limit that particular infection.

    02:05 Now, we all know that some of us suffer worse than others with the common cold, and the thing called a "man cold," it's a thing.

    02:14 Guys just suffer so much worse Unlike this fabulous patient who modeled for the camera, who is simply just blowing her nose, she doesn't look like death warmed over, unlike certain men that I know if they were to get a cold.

    02:27 However, we all know what the typical clinical manifestations are: sneezing, runny nose, headache, sore throat, feeling -- malaise, and then low grade fever.

    02:38 And again, incubation period of 7-10 days, and then treatment or symptomatic course 7-10 days.

    02:47 The common phrase is a cold is 3 days coming, 3 days with you, 3 days leaving.

    02:52 All of those describe the entire prodrome active infection and resolution of active rhinovirus.

    About the Lecture

    The lecture Rhinoviruses – Picornaviruses by Sean Elliott, MD is from the course Viruses.

    Author of lecture Rhinoviruses – Picornaviruses

     Sean Elliott, MD

    Sean Elliott, MD

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