00:01
Now let's talk about the
three types of serum proteins.
00:04
Liver disease or a damaged liver
can cause a decreased amount of
all three of these proteins.
00:10
Now albumin is
produced in the liver.
00:12
So you see in the plasma we've
got albumin right there for you.
00:17
Globulin,
they're made by the liver
while others are made
by the immune system.
00:22
But so far in our
picture you see albumin
and then you've
got the globulins.
00:26
Again, don't memorize those.
00:28
We're just putting this
up here as a visual
so you can get a good good framework
of what we're talking about.
00:32
Now I promised you a three
types of serum protein,
one was albumin
the second or the globulins,
but I want to zero
in on fibrinogen.
00:42
Now, you see that over on
the right of your screen.
00:45
It's produced in the liver.
00:47
We've got the
normal values there,
again just as a
frame of reference,
but take away from this slide
three types of serum
protein albumin,
globulins,
and we're going to
focus in on Fibrinogen.
01:02
So let's take a look
at that fibrinogen.
01:04
I've got a picture up there to
help you kind of make sense of it.
01:08
This is how a clot forms.
01:09
Now remember fibrinogen is one
of three important proteins
that the liver makes
so the serum proteins
are made in the liver.
01:17
But disease livers
don't make them very well
they don't make enough
adequate amounts
of these proteins.
01:23
So fibrinogen is one of
the coagulation factors
one of the things that helps
make a normal blood clot.
01:30
Now it's converted by thrombin into
fibrin which helps build a clot.
01:35
So look at the bloodstream,
you've got there.
01:36
Let's pretend up
at the top there.
01:38
We've got damage to
that blood vessel.
01:41
So what normally happens you see
we've got flowing through here.
01:43
We've got red blood cells.
01:45
We've got leukocytes otherwise
known as white blood cells
and you see some platelets.
01:50
Now, we've got this fibrinogen
that's turned into fibrin
and that kind of
gives us this net
that's catching everything.
01:57
That's how it starts to
collect and weave this plug
that will cap off
and stop bleeding
because remember fibrinogen
is converted into thrombin
by fibrin which helps
us build a clot.
02:11
Perfect,
all right,
so see the picture there,
you've got the idea,
we have damaged then we
have the fibrinogen is
what helps us kind of
build this web to collect
the platelets and the other
blood cells to help heal and fix
that leaky area of
the blood vessel.