Overview and Calculations – Renal Glucose Transport and Reabsorption

by Carlo Raj, MD

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    Glucose. In that previous graph by chance, if you were a little confused, it absolutely warrants further discussion so much so that we need to take a look at this in great detail. So that whole graph with glucose is just giving you an overview, but if you don't understand or if you haven't understood the depths of glucose handling or renal handling of glucose might be little complicated, but let us now simplify things and be more technical. To begin with, we have filtered load. What does that mean to you? It means that what is coming through the efferent arteriole and approximately 20% which is then your filtration fraction and how much do you have left on the efferent side if it is renal plasma flow? It will be 480. What is the normal renal plasma flow coming in? Approximately 600. So 120 has come through and filtered and we are left with 480. Want you to continue. Set up this picture here that you are seeing on the left and now we are at the level of the peritubular capillaries. You see that big fat red arrow? That is your peritubular capillary and now there is modification is taking place in the nephron. You see that yellow arrow. That represents your nephron. Are we clear? Where we are in a nephron represents the proximal convoluted tubule? The PCT. That is where the majority of our modification of our urine will be taking place at this juncture. Reabsorption, what does that mean to you? You are bringing that substance from the lumen, from the urine back into the blood. What does secretion mean? It means that you are putting the substance into the urine. Let us talk about glucose. Should you normally find glucose in your urine completely...

    About the Lecture

    The lecture Overview and Calculations – Renal Glucose Transport and Reabsorption by Carlo Raj, MD is from the course Renal Diagnostics.

    Included Quiz Questions

    1. making it the most susceptible to ischemia Proximal Convoluted tubule
    2. Descending loop of henle
    3. Thin ascending loop of henle
    4. Thick ascending loop of Henle
    5. Distal convoluted tubule
    1. (GFR) x (plasma concentration of substance)
    2. (urine concentration) x (urine flow rate) / (plasma concentration)
    3. (renal plasma flow) / (urine concentration) x (flow rate)
    4. (plasma concentration of substance) x (renal plasma flow)
    5. (Urine concentration) x (GFR)
    1. Plasma concentration exceeds the renal threshold for reabsorption.
    2. It is secreted into the lumen after reaching the threshold.
    3. More than one correct answer.
    4. Complete saturation of the GLUT transporters on the basolateral membrane.
    5. Blockage of GLUT transporters on the basolateral membrane.
    1. Reabsorbed and not secreted.
    2. Once transport maximum has been reached.
    3. Filtered load is always greater than excretion.
    4. Freely filtered, neither secreted nor reabsorbed.
    5. Secreted and not reabsorbed.
    1. When all the transporters are saturated.
    2. When glucose if first seen in the urine.
    3. The first instance that a substance appears in the urine.
    4. The number at which facilitated diffusion become necessary.
    5. The maximum number of transporters on the membrane.
    1. Glucose clearance = GFR
    2. Glucose clearance < GFR
    3. Glucose clearance > GFR
    4. Plasma glucose concentration x glucose clearance = GFR
    5. Urine glucose concentration x glucose clearance = GFR
    1. It is reabsorbed at low concentrations.
    2. At low concentrations it approximates renal plasma flow.
    3. At high concentrations it approximates GFR.
    4. It is fully secreted at low concentrations.
    5. It is freely filtered.
    1. Filtered load > excretion rate.
    2. Filtered load = excretion rate.
    3. Not enough information.
    4. It depends on the renal threshold level of glucose.
    5. Filtered load < excretion rate.
    1. …renal threshold.
    2. …fractional excretion.
    3. …filtration fraction.
    4. …filtered load.
    5. …transport maximum.
    1. It refers to the difference between the renal threshold and the Tmax.
    2. It represents the excretion of a substance once Tmax has been reached.
    3. It is the maximum amount of transporters being saturated
    4. It is the earliest signs of glucose in the urine.
    5. It explains the variations in glycosuria between patients.

    Author of lecture Overview and Calculations – Renal Glucose Transport and Reabsorption

     Carlo Raj, MD

    Carlo Raj, MD

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