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Renal Clearance Equations

by Thad Wilson, PhD
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    We have a few other relationships that we need to bring out. And that is, there are a number of factors that we need to try to calculate. We can use various calculations in the renal system by using this clearance equation. Now, the clearance equation is looking at the concentration of a substance in the urine times the urine formation rate, which is V, over the plasma concentration of the substance, and that clearance equation won’t change throughout our various substances that we’re going to look at. Interestingly though, you can pick a certain substance to look at that will give you insight into the function of the kidney. Inulin is one of these substances. We can use inulin as an index to measure glomerular filtration rate. How you do that is take glomerular filtration rate times the concentration of inulin in the urine, times the urine formation rate, divided by the plasma concentration of inulin. Creatinine is another way to measure glomerular filtration rate. We utilize the very same equation. The only thing we’re doing is substituting creatinine for the X. So here, we have the urine concentration of creatinine, times the urine formation rate, divided by the plasma concentration of creatinine. So both of these two substances can be utilized to measure glomerular filtration rate. Inulin is a little bit more accurate, but creatinine is made in the body, and therefore, it’s more functional. So you can measure someone’s creatinine much easier than you can induce or introduce inulin into someone. The last substance that we can utilize in this clearance equation is PAH. PAH is utilized to help us for renal plasma flow. We use the same equation. All we’re doing is substituting PAH for the X. Here, we have renal blood flow, or renal plasma...

    About the Lecture

    The lecture Renal Clearance Equations by Thad Wilson, PhD is from the course Renal Physiology.


    Included Quiz Questions

    1. Para-aminohippurate
    2. Inulin
    3. Creatinine
    4. Carnitine
    1. Inulin
    2. Creatine
    3. Hippuric acid
    4. Carnitine
    5. Insulin
    1. GFR and plasma concentration of sodium
    2. Plasma concentration of sodium
    3. Plasma concentration of sodium and renal blood flow
    4. GRF and renal plasma flow
    5. Plasma concentration of sodium and renal plasma flow

    Author of lecture Renal Clearance Equations

     Thad Wilson, PhD

    Thad Wilson, PhD


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