Lectures

Regulation of Iron Transport

by Kevin Ahern, PhD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides HemeIronProteins Biochemistry.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    Now, regulation of all three of these proteins is very important. The cell doesn't want to have too much iron, but it also doesn't want to have too little iron. And that regulation largely focuses on the receptor and on the ferritin itself by a very interesting mechanism that I'm going to describe to you now. So, both of the mechanisms for controlling these two proteins involve an iron response element or IRE. This is a structure that appears in the messenger RNA coding for each of these two proteins. This sequence forms what's called a secondary structure that I'll show in the messenger RNA in just a second. The sequence in structure is found in the coding for both the ferritin and the transferrrin receptors and it's also found in some other iron metabolizing proteins, which tells us that again managing the proper amounts of each of these proteins is important just like managing their relative amounts of iron is important. The iron response element works by being a target for binding for a protein called the IRE binding protein. Its acronym is growing. It's called the IRE-BP. Now, the IRE-BP can either bind to IREs in the messenger RNA or it can bind to iron, but it can't bind to both. So the competition which one wins the race to binds it to the IRE-BP? The one that wins the race is the one that's the most abundant. If the iron concentration is high, the IRE-BP binds to the iron, not to the IRE. If the iron concentration is low, the IRE-BP binds to the IRE. Remember, the IRE is part of the messenger RNA. Now, as we will see, this has different effects on these two messenger RNAs. Well, rather than use words, let's go look at...

    About the Lecture

    The lecture Regulation of Iron Transport by Kevin Ahern, PhD is from the course Amino Acid Metabolism.


    Included Quiz Questions

    1. It is bound by the IRE-BP when iron concentration is low.
    2. It is a protein.
    3. It binds to iron when the iron concentration is high.
    4. All of the answers are true.
    5. None of the answers are true.
    1. ...occurs when iron levels are low.
    2. ...favors translation of ferritin.
    3. ...occurs near the 3’ end of the ferritin mRNA.
    4. All of the answers are true.
    5. None of the answers are true.
    1. ...occurs at the 3’ end.
    2. ...protects the 5’ end from nuclease degradation.
    3. ...reduces the synthesis of the receptor.
    4. None of the answers are true.
    5. All of the answers are true.

    Author of lecture Regulation of Iron Transport

     Kevin Ahern, PhD

    Kevin Ahern, PhD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    1
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0
     
    amazing so much only
    By Youssef K. on 25. March 2017 for Regulation of Iron Transport

    this guy so good only amazing so much only omg nice nice