Lectures

Regulation of GFR and RBF

by Thad Wilson, PhD
(2)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides 02 GFR UrinarySystem.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    So glomerular filtration rate and renal blood flow inherently have a link to them. They are not the same parameter though. What you can think about is that glomerular filtration rate is going to be fairly constant across most renal blood flows. The renal blood blow is only constant across an autoregulatory range. If you have too high of pressures or too low of pressures, you’re not going to have the same amount of renal tubule blood flow. If pressure is high, above the autoregulatory range, you’re going to have an increase in renal blood flow. If pressure is below the autoregulatory range, you’re going to have a decrease in renal blood flow. Now, what causes this autoregulatory range to have a fairly consistent blood flow across a wide range of mean arterial pressures? That can be seen in this graph that you see, where you have mean arterial pressure on the X-axis, and blood flow on the Y-axis. There’s a range at which this autoregulation, and that means that through this zone, you’re going to have a fairly constant flow despite the changes in mean arterial blood pressure. What causes that? It’s primarily due to a myogenic response. And what is a myogenic response? That is an inherent local reflex that happens. If you have too much sheer stress across a vessel, it may cause it to constrict. If there’s not enough sheer stress, it will cause it to dilate on its own. So those two local effects allow for you to maintain renal blood flow across a fairly long mean arterial pressure zone. Glomerular tubular feedback is also a very important aspect when trying to determine what renal blood flow is. It doesn’t fit quite as well on this particular graph, so we’re going to use renal tubular...

    About the Lecture

    The lecture Regulation of GFR and RBF by Thad Wilson, PhD is from the course Renal Physiology.


    Included Quiz Questions

    1. Atrial natriuretic peptide
    2. Epinephrine
    3. Norepinephrine
    4. Angiotensin II
    1. Constriction of the vessel
    2. Decrease in arterial pressure
    3. No effect on the vessel
    4. Dilation of the vessel
    5. Tearing of the vessel
    1. Distal convoluted tubule right next to the juxtaglomerular cells
    2. Proximal convoluted tubule right next to the juxtaglomerular cells
    3. Thin descending limb
    4. Distal convoluted tubule right next to the juxtamedullary cells
    5. Thin ascending limb

    Author of lecture Regulation of GFR and RBF

     Thad Wilson, PhD

    Thad Wilson, PhD


    Customer reviews

    (2)
    5,0 of 5 stars
    5 Stars
    2
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0
     
    helpes to understand easily, i recommend it.
    By Eda D. on 02. April 2017 for Regulation of GFR and RBF

    very good explanations helped me to understand easily. Recommend watching it.

     
    Good lecture
    By Rese A. on 06. March 2017 for Regulation of GFR and RBF

    Clear and concise, concepts were explained in enough detail and slowly enough to follow.