Qualitative Traits: Risk Assessment

by Georgina Cornwall, PhD

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    When we assess the risk of a qualitative trait, so these are yes or no traits, either it’s there or it’s not, we can use familial aggregation studies. What on earth is a familial aggregation study? It’s probably a little bit more familiar than it even sounds. But we presume that if an allele increases the chance of developing a disease, we’re going to expect that an affected individual to have a greater than expected number of affected relatives. So, does that make sense? The more that the condition exists in relatives, if it exists more in relatives than it does in the general population then we would have a number greater than one. We call this measure of relative risk ratio λr. When we look at λr and it equals one, we have little or no genetic impact. That means the numerator and denominator are similar and probably, mostly just a result of no genetics. If it’s greater than one, we mean there’s a possible genetic predisposition. It’s more likely in relatives than it is in the general population, lambda greater than one. Here is a chart of a number of different lambdas. By no means, you need to remember what the lambdas are, the relative risk ratios or even which ones have particularly high risk ratios. However, I think it’s pretty interesting to look at these lambda values and so do people in genetic counseling for sure. All of these are conditions that are said to have a genetic component. We will dig into a couple of these in a little bit more detail later in a future lecture. Case control studies are another way that we can assess the genetic contribution. We compare these two unrelated individuals. So, married couples or couples in general are a great...

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    The lecture Qualitative Traits: Risk Assessment by Georgina Cornwall, PhD is from the course Multifactorial Inheritance.

    Author of lecture Qualitative Traits: Risk Assessment

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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