Protease Inhibitors – HIV Drugs (Nursing)

00:01 Now 3 is replication.

00:03 We don't have any medications to talk to you about today for this specific phase.

00:07 So we've got him in binding infusion, conversion and integration, but I don't have any specific drugs to talk to you about today in replication.

00:15 So we're going to move on to that fourth phase but just remember here's what happens in replication.

00:21 The infected T helper cell produces more HIV proteins.

00:25 These are used to produce more HIV particles inside the cell.

00:29 Replication makin copies.

00:32 So this is what we're addressing there and I don't have any drugs for you and that section the third, but we're do have some options in the assembly budding and maturation stages.

00:43 Okay so here's what goes on in the stage.

00:46 The new HIV particles are released from the T helper cells into the blood stream.

00:50 Now they begin to infect other cells and the process begins again and again and again, and again.

00:57 That's why keeping the number of HIV viruses in the bloodstream is our goal for the patient.

01:04 Now protease inhibitor drugs stop this from happening.

01:08 So make sure you've got that in your for stage or diagram right in this the fourth stage protease inhibitor drugs because these are the ones that stop this phase.

01:19 So they're among the most effective of the antiretroviral drugs.

01:23 Now there are nine available.

01:25 So we've got lots of options there.

01:28 We using combinations with an NRTI.

01:30 It can really help reduce the viral load to an undetectable level.

01:35 So you can see that it's complex.

01:36 We've got a whole menu of drugs to choose from including just nine in this category.

01:41 That's why the healthcare provider really make some decisions in evaluating the patient their ability to be compliant their willingness to use an injectable and those other variables to see what's going to be most effective for them.

01:54 This like all the others needs consistency so that we can prevent resistance.

02:00 So when you're thinking about that concept as a nurse.

02:03 We are the ones who are the guards, right? We want to make sure that patients understand in a non-judgmental non-threatening way that hey we want these drugs to be effective.

02:14 So really working towards preventing resistance.

02:18 We want these drugs to be effective for you for a very long time.

02:22 That's another encouragement to them to take them consistently or to problem solve with us any issues that arise why they can.

02:30 Now this group has some different adverse effects think of the effects as a group overall by the phase or the stage in the lifecycle.

02:39 This one can elevate blood sugar.

02:41 So protease Inhibitors can really elevate blood sugar.

02:45 We're going to watch that very closely and diabetic clients, but in all clients.

02:50 You can also cause some kind of unusual fat redistribution, elevate their lipid levels in their blood, reduce their bone density and no is after that, right? It can increase bleeding people that already have hemophilia.

03:04 So if the patient has multiple disorders, this is something that has to be considered.

03:09 You know, if the patient got HIV early from a blood donor.

03:14 And because they're getting the blood because of the hemophilia, now they end up with HIV you can see how some people have a really complicated course of therapy that reduces bone density and that resists the mineral bone density.

03:27 So it's kind of the same thing there that we've got it for you twice just to really make a point.

03:32 We can also have an elevation of serum transaminase.

03:36 Okay.

03:37 This is like a whole list of things that we've got for you to look at.

03:41 So I want you to stop and pause and take some time and think about what your strategies what works best in your brain for you to group or chunk this information together.

03:51 So you'll remember this pretty significant list of possible adverse effects for a patient taking a protease inhibitor.

04:04 So here's some examples.

04:05 Remember we told you there are a lot of them.

04:07 Look at that.

04:08 What do they have in common? When your brain is taking a look at this? What do you notice is the same between every one of these protease inhibitor medications? Okay, they end in "VIR" wait a minute even one more letter they end in AVIR.

04:25 So that is a clue to you to recognize these as protease inhibitor drugs.