Polymorphic Neutrophils Activated (PMN) – Changes in the Exudative Phase (Nursing)

by Prof. Lawes

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    00:01 The PMNs are pretty impressive, so I want to give them their due.

    00:05 So let's hang out here for just a minute.

    00:07 I put a box around them to highlight them.

    00:10 So, you know exactly what I'm talking about.

    00:13 Because these little critters are amazing.

    00:16 Now, they're the most common subtype of the white blood cells.

    00:19 Remember there's five subtypes of white blood cells, but this is the most common.

    00:24 Now, they are short-lived and highly mobile.

    00:27 Look at that.

    00:28 That's why these will fillers can jump from the bloodstream into the alveoli.

    00:32 These guys can enter parts of the tissue where other cells and molecules cannot.

    00:37 So they're short lived but they move really quick.

    00:40 They're highly, highly mobile.

    00:43 Keep in mind, what are we talking about? The PMNs, good! Short-lived, highly mobile.

    00:49 That's how they make it into the alveoli.

    00:52 You've got a really good picture there of what a PMN would look like.

    00:56 So when you're thinking about these guys, I want you to picture this graphic that I have there for you.

    01:02 You keep in mind, they are the most common subtype.

    01:05 They're short-lived, they're highly mobile.

    01:07 And let's look at that third point.

    01:10 Now these guys have another skill set.

    01:12 They can actually ingest infectious agents and other cells and foreign material.

    01:18 Not bad.

    01:19 They can do a lot of things in a very short period of time.

    01:24 Now, they do other things in the cells and this is a sign of when the party's getting out of control.

    01:30 Let's look at three of them.

    01:32 The neutrophils release proteases.

    01:35 Hey, anytime you see the letters ASE think about enzyme.

    01:39 You know what enzymes do they cause a reaction, they break things up.

    01:43 And so anytime you see the letters ASE, it's breaking down whatever is in front of those letters.

    01:49 In this case, one of the three ways, the neutrophils, let the party out of control, is they release proteases, protein digesting enzymes.

    02:00 There's the first one.

    02:02 Here's the second one.

    02:04 The neutrophils will release reactive oxygen molecules.

    02:08 These are bad boys because they cause free radical damage.

    02:13 So, we got the proteases, we've got reactive oxygen molecules.

    02:17 Number three is the neutrophils release more cytokines.

    02:24 This is when things get really crazy, because you know what cytokines do, that's what's started this whole process.

    02:32 The neutrophils will release more cytokines which insights and perpetuates the inflammatory response.

    02:39 So, see how you get stuck in this party that is way out of control in the alveoli.

    About the Lecture

    The lecture Polymorphic Neutrophils Activated (PMN) – Changes in the Exudative Phase (Nursing) by Prof. Lawes is from the course Acute Respiratory Distress Syndrome (ARDS) (Nursing).

    Included Quiz Questions

    1. Can enter tissues where other cells molecules cannot
    2. Can release more cytokines
    3. Can ingest infectious agents and foreign material
    4. Can release proteins
    5. Can release nonreactive oxygen molecules

    Author of lecture Polymorphic Neutrophils Activated (PMN) – Changes in the Exudative Phase (Nursing)

     Prof. Lawes

    Prof. Lawes

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