Plasma Membrane Proteins Create Unique Domains

by Richard Mitchell, MD, PhD

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    00:00 Another big concept.

    00:02 So, plasma membrane proteins can create unique domains.

    00:06 Okay, we've talked about channels and things like that, but in fact, you can have proteins that insert, and then they like to interact with each other, and we can create little postage stamps on the surface of the cell that will allow you to have certain functionality.

    00:24 So, for example, we talked about the lipid rafts.

    00:26 In lipid rafts is a protein called caveolin, and that caveolin is gonna be important for driving the cell sipping.

    00:34 Well, caveolin likes to be in the lipid rafts, so it likes to associate with other caveolae molecules.

    00:40 And so, it's forming a specific domain.

    00:43 So, that's what's being shown here.

    00:44 Proteins associated with each other, forming a domain.

    00:47 When they form a domain too, they can interact with the outside world.

    00:51 So, you can have spot welds that hook a cell to the outside world through transmembrane protein interactions because they're all linked there together.

    01:00 A single protein might not be able to make that happen, but if I have a hundred of them together in a membrane, that's gonna be a pretty good spot weld to hold it in place.

    01:09 Similarly, transmembrane proteins can also act -- interact with intracellular cytoskeletal proteins to provide signaling.

    01:18 And we will talk about this.

    01:19 About how we can have -- we can pull on a transmembrane protein, and a mechanical stimulus will get to the nucleus.

    01:26 Finally, by having proteins transmembrane on each side, cells can interact one with another through those proteins.

    01:36 And it may be the same protein, in which case it's called a homotypic interaction, as shown here with the green squares.

    01:42 It may be different proteins but having domains one to another allow cells to communicate, to contact, to be held together.

    01:51 And one protein doing that would not be enough.

    01:54 We probably need to have a hundred or so on the surface of the cell.

    01:58 Okay, so point here, plasma membrane proteins create unique domains.

    About the Lecture

    The lecture Plasma Membrane Proteins Create Unique Domains by Richard Mitchell, MD, PhD is from the course Cellular Housekeeping Functions.

    Included Quiz Questions

    1. They allow easy communication between cells.
    2. They protect against viral infections.
    3. Synthesis of adenosine triphosphate occurs within them.
    4. They protect against reactive oxygen species.
    5. They permit sorting and modification of other proteins.

    Author of lecture Plasma Membrane Proteins Create Unique Domains

     Richard Mitchell, MD, PhD

    Richard Mitchell, MD, PhD

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