00:01
Let's go through a case.
00:03
A 51-year old man comes to
the emergency department
for severe headache
that developed suddenly.
00:09
Soon after
the headache began,
he was unable to see
out of his left eye,
and vision in his right eye
became blurry.
00:17
He vomited in the
emergency department.
00:20
Medical history is significant
for erectile dysfunction,
loss of libido, and mild headache
over the past two years.
00:28
On physical examination,
his temperature is 36.4 degrees Celsius.
00:33
His blood pressure is
140 over 90.
00:35
His pulse rate is
100 beats per minute.
00:39
On visual field testing,
there is loss of vision in his left eye
and in the upper quadrant
of his right eye.
00:47
He also has
left eye ptosis.
00:50
Other cranial nerves
are intact.
00:52
The rest of his neuro exam
is normal.
00:55
A CT scan of the head shows
acute pituitary hemorrhage,
and MRI shows
a two by two by three centimeter
pituitary mass
with central hemorrhage.
01:07
The mass compresses the optic chiasm
and the left cavernous sinus.
01:12
What is the next step
in the treatment of this patient?
Here we have a fairly
complicated presentation.
01:20
Headache and vision changes
suggest a stroke,
but more specifically,
a bleed within the brain.
01:26
Clinically, the air of the optic chiasm
is suspected.
01:30
Erectile dysfunction and loss of libido
provided on history
also point towards a conclusion
that a pituitary lesion may be involved.
01:40
If we put together the presence
of the visual findings
with the reproductive findings
of loss of libido,
we come up with the area of the brain
localized to the anterior pituitary
where increase in mass
or hemorrhage is going to result
in compression symptoms
on the optic chiasm which lies close by.
02:00
The conclusion here is that the next step in treatment
would be pituitary surgery.
02:05
Stress-dose steroids should also be provided
because of a reduction in cortisol,
and the assessment of his pituitary hormone function
should take place as well.
02:15
Acute apoplexy of the pituitary
is caused by pituitary hemorrhage
and requires urgent transsphenoidal
decompression to preserve vision.
02:25
Loss of libido
and erectile dysfunction,
usually due to reduced
FSH and LH,
suggest that a prolactinoma
has developed
that actually bled and compressed
the patient's optic nerve.
02:37
Raised intracranial pressure can cause vomiting
as manifests in this patient.
02:42
He also requires urgent
stress-dose glucocorticoids
because of the risk of
secondary cortisol deficiency,
which can be
life threatening.
02:51
As the pituitary mass,
so hemorrhage increases,
and there is pressure
on the pituitary,
reduction in ACTH causes
a reduction in systemic cortisol.
03:01
This can lead to
circulatory shock,
and as a consequence,
giving the patient glucocorticoids immediately
will mitigate this risk.
03:11
In the next two to four weeks,
thyroid function will need to be assessed
by checking thyroxine
which has a longer half-life,
so does not need to be
emergently addressed.
03:23
Treatment of hypogonadism
or growth hormone deficiency is also not urgent,
but surgical decompression of the pituitary
is mainly to preserve vision.