So, in a nutshell, let's wrap up the
Beta-lactam antibiotics have
a beta-lactam ring.
That's why we call it that because the beta-
lactam ring in their chemical structure
is included in penicillin, cephalosporins,
monobactams, and carbapenems;
those 4 groups of antibiotics.
Penicillin's been around a long time.
It's not as long as sulfonamides,
but it has been around since the 1940s.
Now, beta-lactamases are the energy,
the arch enemy of penicillins, and
can inactivate that drug.
So, when a beta-lactamase
inactivates the penicillin,
we won't be able to treat the infection.
That's why we use those winning
combinations we talked about.
Combining penicillin with clavulanic
acid, tazobactam, or sulbactam
allows the penicillin to overcome
Now, that's way cooler than you're probably
recognizing at this point in your study,
but that was a very, very cool discovery.
Now, how does that penicillin
work? Remember the P,
it penetrates the cell wall and
it weakens the cell wall,
which causes cell lysis and death.
Penicillin only hits the gram-
Remember, it is resistant to gram-negative
infections and the most common side effect
to penicillins is GI distress.
But remember, the most serious
possible adverse effect
is full blown anaphylaxis,
which puts your patient at risk
for severe respiratory distress.
That wraps up our talk of
Thank you for watching this video.