00:01
So cluster is one of the three or
four TACs that we should consider.
00:05
The second is
paroxysmal hemicrania.
00:09
Here we see a chronic
recurrent headache syndrome,
so episodes of headaches but
these are shorter than cluster.
00:15
They're prominent
autonomic findings,
but the duration is
only 2 to 30 minutes.
00:20
Attacks are severe with
unilateral orbital or supraorbital
or temporal pain that
lasts 2 to 30 minutes.
00:28
These headaches are completely
responsive to indomethacin,
and this is very important.
00:33
We see indomethacin responsiveness with
some of the TACs and not with others,
and paroxysmal hemicrania
by rule should be responsive
to good doses of indomethacin.
00:43
And you can see the 150 mg here.
00:46
The headache is accompanied by ipsilateral
conjunctival injection/lacrimation,
nasal congestion/rhinorrhea, eyelid
edema, facial and forehead sweating,
miosis and ptosis.
00:55
So all those autonomic features
that we see with a TAC.
00:59
And patient should have
more than 5 attacks per day.
01:03
There should be no other cause, and have at
least 20 attacks that fulfill this criteria
to meet the clinical diagnostic
criterion for paroxysmal hemicrania.
01:14
There are two forms of
paroxysmal hemicrania,
an episodic form
and a chronic form.
01:20
This is episodic in about
20% of cases with remissions
that can last more
than one month.
01:26
The chronic form has no
remissions within a year.
01:31
And if chronic from onset,
then we think about some other
secondary causes of
this headache syndrome.
01:37
The main differential of episodic
paroxysmal hemicrania is cluster.
01:41
And so paroxysmal
hemicrania and cluster
are important considerations
to differentiate between.
01:47
We can do that and here's
a table showing some
of the differences between
these two syndromes.
01:52
In terms of sex, episodic paroxysmal
hemicrania really favors females
whereas we see cluster
more commonly in men.
01:59
The duration of the
headache is different.
02:02
Cluster was that
15 to 180 minutes,
whereas episodic paroxysmal hemicrania
is typically shorter 3 to 30 minutes.
02:10
The frequency of attacks
we see 1-8 per day
with cluster often with
a nocturnal predominance,
and then 2 to 30 more attacks in patients
with episodic paroxysmal hemicrania.
02:21
And indomethacin responsiveness
is really important.
02:25
So paroxysmal hemicrania should
be responsive to indomethacin
and we only occasionally see
that with patients with cluster.
02:33
What are some of the other
causes of paroxysmal hemicrania?
We can see vascular causes,
infarcts, aneurysms and AVMs.
02:41
Tumors can do this,
pituitary adenomas.
02:43
Occasionally a pancoast tumor with
prominent sympathetic obstruction,
meningiomas and
parasellar gangliocytomas,
inflammatory
lesions, infections.
02:53
And so there are other secondary
causes of this condition
and in patients where the
diagnosis remains obscure,
we do consider additional imaging to
rule out some of those secondary causes.
03:03
How do we treat
paroxysmal hemicrania?
Well, this is important because
indomethacin is the drug of choice.
03:10
It's important for
both the diagnosis
and the treatment
of these patients.
03:15
And indotests can be used to
assess a patient's response,
and typically that is
a therapeutic dose,
more than or at least 150
milligrammes per day of indomethacin.
03:25
20 to 100 milligrammes may be
sufficient for maintenance,
but we consider that higher
dose for the initial test.
03:32
We do consider gastric protection because
one of the side effects of indomethacin
is gastric problems.
03:39
The headache usually recurs
after discontinuation,
and there is no tachyphylaxis
where we need increasing doses
of the indomethacin over time.
03:50
For some patients
we can try NSAIDs,
if indomethacin needs to
be stopped for some reason,
in COX-2 inhibitors are
a treatment of choice.
03:57
Verapamil, acetazolamide,
topiramate have also been used
in certain cases
and been effective.
04:04
Calcium channel blockers may work in
the episodic form of this disease.
04:07
And headaches are usually too
brief to consider abortive therapy
like oxygen or injectables
or other abortive treatments
because of the short
duration of these episodes.