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Parinaud's Syndrome and Weber's Syndrome

by Craig Canby, PhD
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    00:00 In dorsal midbrain syndrome, the lesion is not caused by a vascular insult. Instead, the lesion is caused by a pineal gland tumor. The pineal gland is shown here. If there is a tumor growth, an expansion of that tumor will grow downward and then have an influence or a negative influence on the superior colliculi, for example. Superior colliculi are involved. With further expansion of the pineal gland tumor, you can narrow the cerebral aqueduct which is this communication between the third and fourth ventricles that contains cerebrospinal fluid. With a lesion of the superior colliculi, you will see a classic triad of upward gaze palsy.

    01:09 Pupils will respond to near stimuli but pupils do not react to light and you would have a form of nystagmus known as convergence-retraction nystagmus. A finding associated with involvement of the cerebral aqueduct is that you would have hydrocephalus. You’d have an increased accumulation of cerebrospinal fluid in the third and fourth lateral ventricles. This specific form of this hydrocephalus would be a non-communicating hydrocephalus. Dorsal midbrain syndrome is a vascular lesion. You can see the area that’s damaged. This is a vascular lesion of the posterior cerebral artery. Structures involved in this syndrome would include the corticospinal and corticobulbar tracts. You would also get involvement of the oculomotor nerve. This is the oculomotor nerve here. The nucleus of this nerve is shown in here.

    02:35 The nucleus of the opposite one is shown here. But we do not see the other oculomotor in this level section.

    02:42 We see it here. What are the symptoms associated with involvement of each one of these structural elements? First, let’s take a look at the corticospinal tract symptoms. Again, this is a tract, so the findings will be contralateral.

    02:58 This is a motor descending tract, so we have contralateral paresis of the upper and lower extremities.

    03:06 We’re also involving the corticobulbar tract. So here, we’re looking at innervation of the facial musculature.

    03:17 This would demonstrate contralateral paresis. This would involve the lower facial muscles specifically.

    03:27 A lesion of the oculomotor nerve would produce ipsilateral findings. This would be ipsilateral oculomotor palsy.

    03:41 This will be characterized by a triad of symptoms. The first is lateral strabismus. The oculomotor nerve innervates most of the extraocular muscles. One that’s still intact would be the lateral rectus. Since it’s still functional, that lateral rectus is going to cause a lateral movement of the eyeball. That’s the lateral strabismus component here. Oculomotor nerve also innervates the levator palpebrae superioris.

    04:19 So, if this is paralyzed, the upper eyelid will droop. That’s ptosis. The oculomotor nerve is essential in constricting the pupil, activating the sphincter pupillae. So if that’s paralyzed, the pupil will be dilated.


    About the Lecture

    The lecture Parinaud's Syndrome and Weber's Syndrome by Craig Canby, PhD is from the course Brain Stem. It contains the following chapters:

    • Dorsal Midbrain Syndrome
    • Medial Midbrain Syndrome

    Included Quiz Questions

    1. Non-communicating hydrocephalus
    2. Communicating hydrocephalus
    3. Idiopathic hydrocephalus
    4. Normal pressure hydrocephalus
    5. Non-obstructive hydrocephalus
    1. Dilated pupil
    2. Hyperacousis
    3. Miosis
    4. Facial droop
    5. Impaired gag reflex

    Author of lecture Parinaud's Syndrome and Weber's Syndrome

     Craig Canby, PhD

    Craig Canby, PhD


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    really good
    By INSTANT C. on 21. January 2017 for Parinaud's Syndrome and Weber's Syndrome

    sir very good explainations,,,,,,,,,,following the course,,need more questions,so that it could help in doing uworld and STEP 1 ,,,,thankyou