00:00
Number one is the axon. Now, you're used to seeing this with other neuro cells, but it's a long
slender projection of a nerve cell or a neuron. It's the kind of arm that comes off it. So, that's
what the axon is. Now, what it does is it conducts electrical impulses known as action
potentials. So, when you see those words that's all that means. Action potential is just that
electrical impulse travelling down the axon. It's away from the nerve cell body. So, you have
the cell body and the axons that project off it. Their job is to conduct the electrical impulse
away from the nerve cell body. Now, this function transmits information to the different
neurons, muscles, and glands. Since we are talking about the neuromuscular junction, we're
talking about how it is transmitting the information to the muscles. So, that is the axon's job.
00:53
The body and the axon that extends off of the body, that's what the role is. Now, as we're
going through this, you may want to pause and recall. Stop the video at a point where you feel
like woah, that's enough, and just see if you can recall and reflect what each of the functions
are of these 4 important parts of the neuromuscular junction. Stop. Number 2 is the motor
endplate. Remember, we introduced that in the introduction, talking about the acetylcholine
receptors. Now, number 3 and number 4. Number 3 is the muscle fiber. Number 4 are the
myofibrils. Now, that matters. We have got number 1, that's the axon; number 2, that's the
motor plate; number 3 is the muscle fiber; but number 4 is the myofibrils that are inside that
muscle fiber. So the muscle fiber is a tubular cell. It's called a myocyte. So, that's pretty
important that you remember that word, so it's familiar to you when you see it in other
drawings and discussions. So, it's a tubular cell, look at that, looks like a tube or like a pipe,
and it's called a myocyte. Now, it has lots and lots of chains of myofibrils. Remember, that's
number 4. Those are all myofibrils. So the muscle fiber, which is a myocyte, has many, many
chains of myofibrils in striated muscle. So, myofibrils are the basic rod-like unit of a muscle
cell. Alright, now just for fun, pause the video and cover up the words and see if you can
recall the name and the function of the 4 stops in the neuromuscular junction. Okay, now
let's break it down even more. You have those 4 major areas. I want to take a closer look
at the neuromuscular junction. Now, you can see we have taken out a little small box, and
we've blown it up so you can take a look at it. Now, number 1 represents the presynaptic
terminal. We can look at the prefix. It's p-r-e. That means before the synaptic terminal. So,
that's before the synapse. Number 2, that's the sarcolemma. Now, look at that as it goes
across. The cell membrane of a striated muscle fiber cell is called the sarcolemma. So, it's a
cell membrane, and you see that there in the drawing. Now, number 3 is the synaptic vesicles.
03:22
Now, this is for the neurotransmitter vesicles, so synaptic vesicles or neurotransmitter
vesicles. Now, this is where you store the various neurotransmitters that are released at the
synapse. Okay, so you've got the presynaptic terminal, the sarcolemma that's just the cell
membrane, and the synaptic vesicles are number 3. They are also called neurotransmitter
vesicles, and they store the neurotransmitters that are then released at the synapse.
03:52
Number 4 is the nicotinic acetylcholine receptors. Now, look at this. We've got the nerve and
the muscle, right? So, the receptors are these polypeptides that respond to the neurotransmitter
acetylcholine. Okay, now if that's starting to get confusing, let's go back over just briefly
once again. In the gray color, we're talking about that axon. Right? That's the nerve. Then at
the bottom, you have the muscle. So, we've got these receptors. Where are they located?
Number 4. These are acetylcholine receptors. When they receive the neurotransmitter
acetylcholine, that activates them and allows you to move your muscles. So, this is where the
nerves control the muscles. Stop 4 is the nicotinic acetylcholine receptors. Now, the 5th one
is the mitochondrion. Everyone remembers this from junior high. Right? It's the cell's
powerhouse. People that don't even like science usually remember the mitochondrion is the
cell's powerhouse. That's because they generate most of the cell's supply of chemical energy
known as ATP or adenosine triphosphate.