Neuromuscular Disease

by Carlo Raj, MD

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    Here, we’ll take a look at neuromuscular diseases. Let’s begin. But first, I want you to get an orientation of neuromuscular diseases, but before we do that, taking a section out of a spinal cord, I want you to move from your left. We see a spinal cord. And we’re going to amplify, amplify, amplify, from left to right. I want you to orient yourself to the actual spinal cord where the anterior is on top. Is that clear? But you knew that already because the anterior horn represents motor neuron, doesn’t it? And so therefore, we’ll talk about motor neuron diseases. Not yet. Because our topic here is neuromuscular disease. Now as you move out from the motor, and you get into the CNS – or into the PNS, excuse me. Then, we’ll start to talk about peripheral neuropathies and that’s the other big bracket that you see there. But that’s not the topic yet. I want you to move out from the peripheral nerve and then finally make it out to the muscle. Ah! And then at that muscle is your neuromuscular junction. And at that neuromuscular junction, we’ll talk about a few of these issue of neuromuscular diseases. And at some point in time, when the time is right, we’ll talk about muscle itself undergoing disease and those are myopathies. It’s a beautiful picture to give you an outline as to topics to come. Motor neuron diseases and peripheral neuropathies, myopathies or even neuromuscular disease, which is our specific topic in this section. Under neuromuscular disease, you can do degenerative as being a category. And this is your Lou Gehrig or, a.k.a., amyotrophic lateral sclerosis. With amyotrophic lateral sclerosis, let me give you a brief little introduction. You’ll have motor issues only. Sensory will be intact. ALS....

    About the Lecture

    The lecture Neuromuscular Disease by Carlo Raj, MD is from the course Other Diseases: Hydrocephalus, Neuromuscular Disease, Plexopathy and Mononeuritis. It contains the following chapters:

    • Neuromuscular Disease
    • Amyotrophic Lateral Sclerosis
    • Peripheral Neuropathy

    Included Quiz Questions

    1. Atrophy
    2. Loss of only upper motor neurons
    3. Loss of only lower motor neurons
    4. Hypertrophy
    5. Hyporeflexia
    1. SOD 1 gene on chromosome 21
    2. SOD 1 gene on chromosome 13
    3. SOD 1 gene on chromosome 22
    4. SOD 2 gene on chromosome 21
    5. SOD 2 gene on chromosome 9
    1. Riluzole
    2. Baclofen
    3. Diazepam
    4. Ibuprofen
    5. Amitriptyline
    1. Muscle weakness and muscle atrophy
    2. Difficulty in breathing
    3. Fasciculation
    4. Jerks
    5. Decreased Vital Capacity

    Author of lecture Neuromuscular Disease

     Carlo Raj, MD

    Carlo Raj, MD

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