Multifactorial Gene Disorders: Examples

by Georgina Cornwall, PhD

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    Previously, we’ve talked about how we might tease out some of the genetic contribution of multifactorial gene disorders and pick it out from the environmental components. But probably what you really want to get to is what you really need to know for the exam and some of the common examples. So that’s what we’ll cover in this lecture. First of all, we’ll look at some multifactorial disorders that clearly have a genetic contribution but we don’t really know what it is. Then in the second section, I’ll cover some disorders that we are actually ascertaining what the genetic connections are. Now clearly, because we have the human genome sequence done and sequencing costs are coming down and down and down, we’re going to learn more and more about where all of these genetic disorders might lay. But prior to now, it’s been exorbitantly expensive to just do a genetic screen on everyone. Let’s move on and look at the three main types of disorders that I’ll cover in the beginning of this lecture where we know there is a genetic component but we don’t know what it is. We have some congenital heart disorders. There’s actually a lot of those that we have quite a good understanding about as well as neuropsychiatric disorders. We’re going to look at schizophrenia and bipolar disorder. Finally, we’ll look at coronary artery disease. As you've probably heard, it potentially has some genetic links, so why not discuss those here. We’ll begin by looking at some congenital heart disorders. These are a specific subclass of congenital heart disorders that have to do with flow through the heart. I bring them up not because you should know the values or the symptoms or any of that, just because there are some disorders associated with genetics....

    About the Lecture

    The lecture Multifactorial Gene Disorders: Examples by Georgina Cornwall, PhD is from the course Multifactorial Inheritance. It contains the following chapters:

    • Multifactorial Gene Disorders - Examples
    • Schizophrenia

    Author of lecture Multifactorial Gene Disorders: Examples

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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