Movement of Larger Molecules Across Membranes: Phagocytosis

by Richard Mitchell, MD, PhD

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    00:01 So, that's been potocytosis and pinocytosis, cell drinking.

    00:05 Next up is phagocytosis.

    00:08 And phagocytosis is generally done only by specialized phagocytes or cells that eat.

    00:14 To a limited extend, every cell has the capacity to eat relatively small things.

    00:20 And we will talk about subsequently, eating apoptotic bodies.

    00:25 Small, little buds that come off in apoptotic or cell that is dying due to program cell death.

    00:33 So, phagocytosis will be a lot of cells.

    00:35 But mainly, it's macrophages and neutrophils that do the major job of eating the large things like bacteria.

    00:42 They will internalize it, not using clathrin and not using caveolin, but by a different pathway, and they will engulf that large thing in membrane, internalize it, turn it into a phagosome, and then they will fuse that with a lysosome where then, proteases and other mediators can cause the degradation of whatever has been ingested.

    01:07 This is just a pseudo-colorized scanning electron micrograph of a neutrophil.

    01:13 They are in yellow, that's eating a Bacillus anthracis, a bacteria.

    01:19 One of the forms of bacteria. This is one that actually causes anthrax.

    01:22 So, you can see that it -- you can actually eat something that's substantially larger than you are under appropriate circumstances.

    About the Lecture

    The lecture Movement of Larger Molecules Across Membranes: Phagocytosis by Richard Mitchell, MD, PhD is from the course Cellular Housekeeping Functions.

    Included Quiz Questions

    1. It plays a primary role in the defense against microbial pathogens.
    2. It occurs at lipid microdomains.
    3. It is mediated through clathrin protein.
    4. It mainly transports the liquid droplets across the cell membrane.
    5. It is involved in the metabolism of low-density lipoproteins.

    Author of lecture Movement of Larger Molecules Across Membranes: Phagocytosis

     Richard Mitchell, MD, PhD

    Richard Mitchell, MD, PhD

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