Meglitinides (Glinides) – Oral Antidiabetic Medications (Nursing)

00:01 Our third group of meds are meglitinides or the glinides.

00:06 Now, these also encourage the pancreas to secrete insulin.

00:09 So, ready for another question? What are the names of the first 3 types of oral anti-diabetic medications we've discussed? Don't look, and see if you can come up with the names of the families or the classes.

00:30 Now that you've gotten those down, I've got a hint for you.

00:33 There's a B, an S, and an M.

00:36 That's the first letter of each of those families or classes.

00:40 Now, let's see if you're really up to the challenge.

00:43 Match these medications to each one of those 3 classes.

00:54 Okay.

00:55 That was a good check.

00:57 Make sure that you're asking yourself questions back and forth as you go through the content.

01:01 It'll make it a lot easier for your brain to remember.

01:04 So, take a little bit of information in, then quiz yourself.

01:07 Take a little more information in, and quiz yourself again.

01:10 The more you keep doing that through your studying, I promise you, you're going to get great results.

01:15 Let's get back to the glinides.

01:17 Now, these have the same mechanism as the sulfonylureas, so reason I want you to know that is these stimulate the pancreas to secrete more insulin.

01:26 That's why it won't work with type 1 diabetics because the pancreas, she's dead.

01:32 But, if sulfonylureas weren't effective, then the glinides won't be effective, either.

01:37 So if you try to treat a patient with sulfonylureas and it wasn't affected, the healthcare provider won't order the glinides either.

01:44 But it also has the same risk for low blood sugar, so keep that in mind.

01:49 The glinides are shorter-acting than sulfonylureas, and they're taken with each meal.

01:54 So that's some of the differences between these 2 drugs that have the same issue with low blood sugar because they will drop any blood sugar, and they stimulate the pancreas to put out more insulin.

02:06 We've listed 2 members of the meglitinides family up there for you on this slide.

02:11 Now, either one of these can be used by themselves, monotherapy, or with metformin to be effective.

02:17 But I want you to look at this next point.

02:19 Which one of the 2 medications has a shorter onset and duration than the other? Make sure you underline that, and keep in mind, and compare 1 to the other, that one has a shorter onset and duration.

02:32 Now, what's most important for you to remember is just that these medications can be used by themselves, or they might be used with metformin.

02:40 The other point is just nice to know.

02:45 This is really crucial.

02:46 30 minutes is important.

02:48 Because this medication causes low blood sugar, if your patient takes the medication, you want them to make sure they have food no longer than 30 minutes because of that risk of low blood sugar.

03:00 Now, if they're talking another drug with this, here's another nice-to-know thing.

03:03 This is a drug interaction.

03:05 If they're taking the drug, gemfibrozil, this will cause elevated levels of glinides, so you'll work together with your healthcare practitioner to know that they can't take the glinides and this medication.

03:17 It will put them at an increased risk for toxicity.