Our third group of meds are
meglitinides or the glinides.
Now, these also encourage the
pancreas to secrete insulin.
So, ready for another question?
What are the names of the first 3 types of oral
anti-diabetic medications we've discussed?
Don't look, and see if you can come up with
the names of the families or the classes.
Now that you've gotten those
down, I've got a hint for you.
There's a B, an S, and an M.
That's the first letter of each
of those families or classes.
Now, let's see if you're
really up to the challenge.
Match these medications to
each one of those 3 classes.
That was a good check.
Make sure that you're asking yourself questions
back and forth as you go through the content.
It'll make it a lot easier
for your brain to remember.
So, take a little bit of information
in, then quiz yourself.
Take a little more information
in, and quiz yourself again.
The more you keep doing
that through your studying,
I promise you, you're going to get great results.
Let's get back to the glinides.
Now, these have the same
mechanism as the sulfonylureas,
so reason I want you to know that is these
stimulate the pancreas to secrete more insulin.
That's why it won't work with type 1
diabetics because the pancreas, she's dead.
But, if sulfonylureas weren't effective, then
the glinides won't be effective, either.
So if you try to treat a patient with
sulfonylureas and it wasn't affected,
the healthcare provider won't
order the glinides either.
But it also has the same risk for low
blood sugar, so keep that in mind.
The glinides are shorter-acting than
sulfonylureas, and they're taken with each meal.
So that's some of the differences
between these 2 drugs
that have the same issue with low blood sugar
because they will drop any blood sugar,
and they stimulate the pancreas
to put out more insulin.
We've listed 2 members of the meglitinides
family up there for you on this slide.
Now, either one of these can be used by themselves,
monotherapy, or with metformin to be effective.
But I want you to look at this next point.
Which one of the 2 medications has a
shorter onset and duration than the other?
Make sure you underline that, and keep in mind,
and compare 1 to the other, that one
has a shorter onset and duration.
Now, what's most important for you to remember
is just that these medications
can be used by themselves,
or they might be used with metformin.
The other point is just nice to know.
This is really crucial.
30 minutes is important.
Because this medication causes low blood
sugar, if your patient takes the medication,
you want them to make sure they
have food no longer than 30 minutes
because of that risk of low blood sugar.
Now, if they're talking another drug with
this, here's another nice-to-know thing.
This is a drug interaction.
If they're taking the drug, gemfibrozil,
this will cause elevated levels of glinides,
so you'll work together with your
healthcare practitioner to know
that they can't take the
glinides and this medication.
It will put them at an
increased risk for toxicity.