00:00
Alright, on the next slide,
I'm going to show you
a whole list of things
that can cause
low urine specific gravity.
00:07
But I want to give you a framework
before I even show you that
so you can kind of group them
into categories.
00:14
The first category is
endocrine.
00:16
The second one is glomerulonephritis
or pyelonephritis.
00:20
And the third one is just
straight up renal failure.
00:23
Okay, so keep those categories
in mind.
00:26
If I have a patient
whose results come back
with low urine specific gravity,
these are the categories on our run
through my brain,
is it an endocrine problem?
Is it a problem with
glomerulonephritis
or pyelonephritis?
Inflammation of the kidney?
Or is it renal failure?
Okay, so here it comes.
00:44
I've got a long list for you
but remember,
we've given you those categories
to think through.
00:50
Now,
diabetes insipidus
that falls in the
endocrine category.
00:54
That means
I don't have enough ADH,
antidiuretic hormone.
01:00
So let's use this time to kind
of help solidify that concept
in your brain.
01:05
So next to DI or
diabetes insipidus.
01:08
I want you to write
a downward arrow and ADH.
01:11
Just to remind you that that's the
opposite of SIADH,
which is extra ADH.
01:17
Now because your body is just
dumping off water
because it doesn't have the
chemical messenger to tell it
to hang on to it.
01:25
Because that's what ADH is job is
it's against diuresing.
01:29
So if I don't have that hormone
in my body,
I am dumping off
all extreme amounts of fluid.
01:36
That's why my urine
will look like water
and have a
low specific gravity.
01:40
Now, in kidney failure,
the kidneys are not going to
be able to concentrate the urine
and that's why you also may have
a low specific gravity.
01:49
Now, the next one's
just dealing with again,
more damage
to your kidneys
but we're getting
real specific.
01:55
The official diagnosis is
acute tubular necrosis
that means you have damage
to kidneys tubular cells,
we just call it
acute tubular necrosis,
which means
death.
02:06
Definitely qualifies
as damage.
02:09
Pyelonephritis or
glomerulonephritis,
or inflammation in the kidneys.
02:13
So that was its own category.
02:15
But that's a pretty involved
diagnosis.
02:17
So you want to check out
our videos
that go in depth
in these two diagnoses.
02:23
This one is unusual.
02:24
You may think
you'll never see it,
but I have seen it more times
than I wish in my career.
02:30
Psychogenic,
means genic is the cause,
or the beginning is psyche.
02:35
That's your brain.
02:36
So people with certain
mental health diagnoses
can develop psychogenic,
poly meaning many
have this extreme thirst
that they cannot satiate.
02:48
They just drink, and drink,
and drink, and drink, and drink
and I'm not doing
it justice.
02:54
These patients are driven to drink
more than their body can handle.
02:58
Meaning they end up throwing their
electrolytes off so much
that it becomes life threatening.
03:02
People have actually died from
psychogenic polydipsia.
03:06
So keep that in mind.
03:08
The reason their urine has this
low specific gravity
in the first case
was because
you didn't have enough
endocrine, right?
They didn't have enough
hormone and diabetes insipidus.
03:18
The next two items are because
the kidneys taken a hit,
and it's not really
functioning well.
03:23
So endocrine
was the first one,
kidney failure,
damage to the tubular cells,
pyelonephritis,
glomerulonephritis
those are all
damage to the kidney.
03:32
But psychogenic polydipsia
is a case kind of all by itself.
03:36
The last one is
malignant hypertension.
03:40
Okay, now malignant,
that's bad, right?
That's real bad
when it says malignant.
03:44
We normally think about that
with cancer.
03:47
But when you put it
with hypertension,
that means blood pressure
that is so high.
03:53
It's kind of put your life at risk.
03:55
I have a stroke and
I have other experiences
but what do we know
about the kidneys
Remember, we've traced
that blood supply.
04:03
Blood is delivered
to the kidneys.
04:05
When you hit that glomerulus,
it's a tingle of capillaries.
04:08
We know that capillaries
are really fragile
because things have to go
back and forth
across those membranes.
04:14
So it's meant to receive volume
at a set rate.
04:18
If I have malignant hypertension,
Boom!
those kidneys are
getting hammered.
04:25
So that really can mess
with your kidneys.
04:28
Okay, so how could we rearrange
this list of things that we have?
Endocrine.
04:33
Ah, just that one.
04:35
Diabetes insipidus,
When you have kidneys
that are taking a hit,
which ones fall
into that category?
Everything else except
psychogenic polydipsia.
04:46
So if I'm looking at
a list like this,
I'm thinking, can be
an endocrine disorder,
the kidneys have been
taken a hit
and there is several reasons
how the kidneys can take it.
04:56
And the very unusual
psychogenic polydipsia.
05:00
There you go.
05:01
Now you're remembering
three things, three categories,
instead of six individual items.