Learning Outcomes – Upper Gastrointestinal Secretion

00:01 But luckily, we’ve been able to go through the constituents of salivary secretions.

00:05 We know how salivary glands work, how they’re controlled and regulated.

00:10 Remember, this occurs from both the sympathetic and the parasympathetic nervous systems but the parasympathetic nervous system is more important than the sympathetic in this case.

00:21 We also know the constituents of gastric gland secretions, and these are things like all the different ions that we talked about, things like hydrogen ions, things like potassium, things like chloride.

00:34 We also went through intrinsic factor and pepsinogen that are also secreted.

00:40 Spent the majority of the time though talking about the control and regulation of hydrogen ion secretions from the parietal cells.

00:48 And this involves a multiple step process.

00:51 Some of them direct, some of them indirect, but we were able to talk through talking about acetylcholine directly stimulating parietal cells, indirectly stimulating both the ECL cells and the G cells to secrete histamine and gastrin.

01:07 And all those work together to stimulate hydrogen ion secretion, and that’s part of that control and regulation of hydrogen ion secretion.

01:18 Then we are able to finally talk through the reason why you can pharmacologically target some of these receptors to decrease acid production.