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Kaposi's Sarcoma-asssociated Herpesvirus (KSHV) – Herpesviruses

by Sean Elliott, MD

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    00:01 Getting now to the end, we have HHV8, or human herpesvirus 8, which has been named Kaposi's sarcoma- associated herpesvirus.

    00:11 Again, you'll mostly hear people say Kaposi's virus.

    00:14 This transmission is via mucosal secretions, so saliva, but especially sexual contact.

    00:22 And the patients who develop diseases with this particular virus are those who are immunosuppressed, either via HIV infection, which is extended to AIDS, or those who are transplant recipients, primarily solid organ transplant patients, because they have a specific very immunosuppressive type of medication which puts them at risk.

    00:44 Patients with a Kaposi's sarcoma will demonstrate lesions such as you see on the images in front of you.

    00:51 . The sarcoma itself is very dark and purplish, violet, to use the proper term, and they're plaque-like And you can actually see, especially in the image on the right, sort of, plaque-like skin on top of a purplish, very circumscribed lesion that actually -- both of those represent vascular proliferation.

    01:11 So, we're having a reactivation to the virus itself, causing -- as a proliferative faction causing the sarcoma.

    01:18 So, think of a sort of vascular or a hemorrhagic appearing plaque with scale on top of it, and that will be your Kaposi's sarcoma.

    01:29 So, that's a longer presentation because the herpesviruses include some very important pathogens, many which we will see quite commonly in medicine.

    01:39 But if you can, sort of, keep in mind the order, so the herpesviruses 1 and 2 are herpes simplex virus.

    01:46 3 is going to be varicella-zoster virus, chicken pox.

    01:50 4 is going to be Epstein-Barr virus, 5 will be cytomegalovirus.

    01:56 6 and 7 are the roseola viruses, and 8 is the Kaposi's sarcoma virus.

    02:02 Put all those together and you got a whole bunch of badness, which unfortunately, we'll all probably see quite frequently.


    About the Lecture

    The lecture Kaposi's Sarcoma-asssociated Herpesvirus (KSHV) – Herpesviruses by Sean Elliott, MD is from the course Viruses.


    Included Quiz Questions

    1. Plaque-like
    2. Vesicular
    3. Pustular
    4. Crusted
    5. Ulcerated

    Author of lecture Kaposi's Sarcoma-asssociated Herpesvirus (KSHV) – Herpesviruses

     Sean Elliott, MD

    Sean Elliott, MD


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