00:01
Hi!
Welcome to our lab series
In this one, I'm going to help
you understand the difference
between urine creatinine
and creatinine clearance
and how that can help you
keep your patients safe.
00:12
Now let's do a quick review.
00:14
Okay, so we're talking about
a creatinine clearance test.
00:17
But what is creatinine?
Remember it's a waste product
when your muscles burn
protein for energy,
you end up with creatinine.
00:26
Now create an can build
up in the blood stream.
00:28
You got to remove it from the
body, right?
That ends up going
out in your urine
when we're talking about a
creatinine clearance test,
we're talking about how
effectively your body does that.
00:39
Now let's go back to a little
bit of your body parts,
there see their
picture on the screen.
00:43
Now, what I'd like you to
do is just take your finger
and put it on one
of the kidneys,
you can pick whichever
one you want.
00:50
Because the job of the kidneys,
these healthy kidneys
are to filter and remove
creatinine from the blood.
00:56
Now it's going to carry that
down to the bladder and
exit through the body.
01:00
So what I'd like you to do is put
your finger on the blue vessel.
01:05
Now, it moves through the kidney
goes through the nephron
and then it sends it down
to the bladder to
leave the body.
01:13
So I want you to
have that concept
because creatinine clearance
depends on a lot of things.
01:17
You have to have
a healthy kidney.
01:19
You have to have
good blood flow.
01:21
So those are some concepts
that we're looking at assessing
when we're looking at a
creatinine clearance test.
01:28
Okay so now we're
up to this test.
01:29
Let's give you the official
definitions for that.
01:32
A creatinine clearance test is
measuring your kidneys ability
to filter and remove creatinine
your bloods got to get
through that kidney
and as it's moving
through the kidney,
this test will tell us how well
it's filtering and removing the
waste products that we want it to.
01:49
Now correct me clearance test takes
more than just a blood sample.
01:53
You need a 24-hour urine sample
and that's kind of a big deal
because it takes a lot
of people participating
to make sure we get
the right sample,
but you need a
24-hour urine sample
and you compare it
with a venous sample
or a blood sample.
02:08
So that's the two things
that you need for a
creatinine clearance test.
02:12
You both a special urine sample
24 hours,
full 24 hours not more or less,
but right exactly at 24
hours and a venous sample.
02:24
So being able to compare
these two will help us see
how well your kidneys are filtering
and removing that from your blood.
02:32
Now we're talking about
normal levels of creatinine.
02:35
You already know when we're
speaking of creatinine,
the muscles are involved, right?
It's a waste product from the
muscles and their energy production.
02:43
So men tend to have a little
bit higher muscle mass.
02:47
That's why their normal levels
for creatinine
clearance is 97-137.
02:52
Females tend to have a
little less muscle mass
and so their levels are
also little lower 88 to 128.
03:01
So how do we measure it?
Well, we usually measure with,
you already know,
we had measure it with both the urine
and the blood sample
and we can also estimate it.
03:10
Now why would we estimate it?
Well, it's back to
that 24-hour sample.
03:14
That's a little problematic.
03:16
You have to have the patient pee, then
you start the sample at a certain time.
03:19
You have to make sure
that it stays cold
and you get every
sample in between,
that's not as convenient
as doing an estimation.
03:26
So we can use this
fancy in math.
03:28
I like to call it's
really not that fancy.
03:31
But we use a mathematical
formula and that'll help us
estimate the same thing.
03:36
We can do the
creatinine clearance.
03:38
Now, you have to
figure some things in,
you see on your notes there,
It says the formula includes
age, race, and gender
that's because there are differences
based on the patient's age,
race, and gender.
03:50
We know that males have higher
muscle mass than females.
03:53
We know as you age your
creatinine levels go up
and certain races also
have higher levels.
03:59
So let's look at the formula
and before you get excited,
don't worry about it.
04:03
If you're a math nerd, lock on have
at it plug your stuff in there.
04:07
But for the rest
of us mere mortals
just know this is
what it looks like.
04:12
This is an example of one of
the formulas that can be used
to estimate
creatinine clearance.
04:18
Now, here's a keynote I always
want to remind students about,
remember you this formula only
works creatinine clearance
only works if the serum
creatinine is stable.
04:29
So that's a key point.
04:30
Also sounds like come
up as a test question,
but remember creatinine
clearance is only accurate
if their serum creatinine
is relatively stable.
04:40
Okay now for women if I want to
adjust this formula for women,
I would just multiply it by 0.85
and I would get the accurate
number for a female.
04:49
Cool, Alright,
so we see a formula,
don't worry about it.
04:53
You don't have to do the math
just know that we
can do the math
and it'll be calculated for
you in a hospital setting
or in a clinical setting.
05:02
What you do want to
take away from this is
most important
the serum creatinine has
to be relatively stable
in order for this to work.
05:10
Women are going to be
a little bit lower.
05:12
And remember this just reminds
us of the different factors
age, gender and race will
also be included in that.
05:21
Not in the actual numbers,
but it's included in
the reporting results.