Integrated Control of Blood Volume: Overview

by Thad Wilson, PhD

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    Now, we are going to put a bunch of the pieces of the puzzle together. We’re going to talk through the control and regulation of blood, and urine volume. To do this, we’re going to step one step at a time through controlling osmolality and controlling volume at the same time. To look at the integrated control of blood volume and osmolality, the first thing that we need to do is to look at the osmolality component. So what is osmolality? This is the amount of solutes in the solvent. The more concentrated the solutes are, the higher the osmolality. This what occurs in the blood if osmolality increases. Where do you sense this change? You have osmoreceptors located in the OVLT and SFO. These will stimulate thirst, as well as AVP, arginine vasopressin antidiuretic hormone release. Let’s go through the AVP portion first. There are certain neurons that are located in the hypothalamus. These are hypothalamic nuclei – the paraventricular nuclei and the supraoptic nuclei. These particular portions will garner the information from the osmoreceptors, and then cause the release of arginine vasopressin. Arginine vasopressin is released into the blood, travels around to the kidneys, and remember, that will allow us to reabsorb more water. If you reabsorb more water, you excrete less. Therefore, there’s more free water in the system that feeds back and will decrease the osmolality because we have more solvent that will dilute the solute in the solvent. Besides retaining more water, you’ll also be able to have a greater thirst so you will garner more water. These thirst receptors are located also in the hypothalamus, and they will allow you to increase water intake – or become thirsty. As you drink more water, you’ll increase the free water in the system, and that too...

    About the Lecture

    The lecture Integrated Control of Blood Volume: Overview by Thad Wilson, PhD is from the course Renal Physiology.

    Included Quiz Questions

    1. Increase in salt craving
    2. Increase in water secretion
    3. Decrease in thirst
    4. Decreased effective circulatory volume
    5. Decrease in angiotensin II
    1. Increased effective circulatory volume
    2. OVLT
    3. SFO
    4. AVP
    5. Decrease in salt drive force
    1. Low blood pressure is recognized via baroreceptors
    2. Juxtaglomerular apparatus signals for increased salt craving and increases the secretion of sodium
    3. Angiotensin II sends negative feedback to the thirst receptors
    4. Blood pressure decreases with the release of Renin
    5. Osmolarity increases when circulatory volume is increased

    Author of lecture Integrated Control of Blood Volume: Overview

     Thad Wilson, PhD

    Thad Wilson, PhD

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