00:01
Let's also talk about the
medications that might be used
to try to treat preterm labor,
once the client comes
to the hospital.
00:09
We may use terbutaline,
magnesium sulfate,
corticosteroid therapy,
and antibiotics.
00:17
Terbutaline is an
adrenergic agonist
and it can be given P.O. or Sub Q.
00:23
The Sub Q dose is 0.25 milligrams
every four hours.
00:27
P.O. dose is typically
2.5 milligrams every four hours.
00:32
There are definitely some clients
who should not receive terbutaline.
00:35
Anyone who has heart disease,
gestational diabetes,
or severe preeclampsia
would not be a candidate
for this medication.
00:44
Expected effects include:
tachycardia, tremors, anxiety,
and transient hyperglycemia.
00:50
However, terbutaline has a
"black box warning" from the FDA.
00:54
And prolonged oral exposure may
lead to serious complications like
hypokalemia, arrhythmias,
pulmonary edema,
and myocardial ischemia.
01:04
Magnesium sulfate may also be given.
01:08
Now, we give magnesium sulfate
in preeclampsia
because it's a CNS depressant.
01:12
In preterm labor,
it does double duty
because it relaxes smooth muscle,
it's frequently used as primarily
a tocolytic.
01:20
It also offers some neuroprotection
for the preterm fetus.
01:25
It's used in preterm labor reduces
the risk of neurologic problems
and cerebral palsy, and
babies born very premature.
01:33
An initial bolus of four grams,
followed by one to two grams
per hour by infusion is typical.
01:40
Therapeutic range
for magnesium sulfate
is somewhere between
4 and 4.7 milliequivalents
per liter.
01:48
When we're giving someone
magnesium sulfate for any reason,
we need to monitor
for signs of toxicity,
and that includes pulmonary edema,
absent deep tendon reflexes,
hypotension,
altered level of consciousness,
a respiratory rate less than 12,
or a heart rate that's less than 60.
02:08
Those are going to be things
we absolutely need to check.
02:11
We should also be aware
that these babies
may need more help
than usual at delivery.
02:16
The magnesium does cross
the placenta,
so the babies may be
very sleepy or even apneic
meaning they may not want
to breath.
02:24
The team must be ready for that.
02:27
We can also use other medications
to provide some relaxation,
and one of those medications
is nifedipine.
02:34
This is given orally.
02:36
Usually 30 milligrams
followed by 10 to 20 milligrams
every four to six hours.
02:41
Contraindications include
a history of cardiac disease,
hypotension, and renal disease.
02:48
How does it work?
Well, we have calcium channels,
and if they are activated,
then we'll have a
contracted myometrium.
02:55
So the uterus will contract.
02:57
If we give the nifedipine
we can block the calcium channels,
and that will relax the uterus.
03:03
So it's very effective
in that regard.
03:07
One of the most significant
complications for the newborn
that's born prematurely
is respiratory distress syndrome.
03:14
Fortunately,
we have something that we can do
to help reduce that complication,
and that is to give the birthing
person a corticosteroid.
03:23
Corticosteroids work by
causing a stress response,
which allows for the release
of surfactant in the fetus.
03:30
Now, what a surfactant do?
Surfactant allows for the alveoli
to stay open
when the newborn breeze.
03:37
Otherwise when they breathe,
the alveoli stick together.
03:40
So think about surfactant
like dishwashing detergent
that's really oily,
it allows the alveoli to stay open.
03:46
So we administer the glucose steroid
to the birthing person IM.
03:52
And we do this between
24 and 34 weeks.
03:55
Now, 34 weeks is typically
when the fetus will start to
produce surfactant on their own,
but even all the way up
to 36 weeks and seven days,
we may still give the
corticosteroid just in case.
04:08
They're currently
two corticosteroids that are used
in the hospital.
04:12
Two have the most
common corticosteroids
that are given in hospitals
in the United States
are betamethadone.
04:18
And typically,
this is 12 milligrams,
it's given in two doses
that are 24 hours apart.
04:23
And dexamethasone,
which is six milligrams,
it's given in four doses
12 hours apart.
04:28
This is how we're going to reduce
respiratory distress syndrome
in the newborn.
04:33
Remember, this is what helps
with surfactant production.
04:37
Now, one big caveat
I'm going to give you
is that anytime we give a steroid,
it causes an increase
in our glucose level.
04:45
So it's important that we monitor
glucose levels.
04:49
So if you have a client
who has gestational diabetes
or pre-existing diabetes
who's at risk
for delivering a preterm baby,
the decision may be made
to not give the corticosteroid
or if given to significantly
monitor blood glucose levels.
05:05
The last category I want to talk
to you about in terms of medication
are antibiotics.
05:09
I won't list each one
because the antibiotic that's given
will depend on the type of disease
or bacteria that is suspected.
05:16
But antibiotics definitely will
be ordered if there's a suspicion
that an infection is the
cause of the preterm labor,
or if there's a case of
rupture of the membranes,
especially premature
rupture of the membranes.
05:29
Now, let's try a case and see
if we can put this all together.
05:33
So let's meet Lee Willis.
So Lee Willis is 18.
05:37
Lee Willis is Caucasian.
05:39
Lee Willis is 27 weeks and 2 days,
and this has been verified.
05:43
And Lee presents with
lower abdominal cramping,
a backache for the past 45 hours,
and they've experienced a gush
of fluid about two hours ago.
05:52
So, in thinking about Lee,
what kinds of questions
do you think the nurse should ask?
Hopefully, you asked about
their previous OB history,
to give you more of a description
about the abdominal pain,
to talk about
what the fluid looked like,
and if there's any bleeding?
Maybe you remember to ask about
whether they felt the baby moving,
or they have a support person,
or what was going on
right before this happened.
06:24
Those would all be
excellent questions
to determining
kind of the background
of what's going on
with the symptoms
that leaves experiencing.
06:32
And what items will you include
in your focused assessment?
See if you can come up with some.
06:44
Hopefully, you mentioned
vital signs
both for Lee and
also for the fetus.
06:49
Hopefully,
you mentioned determining whether
the membranes have
actually ruptured.
06:53
You may describe, putting the client
on the fetal monitor
to figure out what the contraction
pattern might look like
and to get an idea
of fetal well being.
07:01
And all of those things together
would definitely let us know
whether Lee might
or might not be in labor.
07:08
Now, maybe you weren't sure
about whether or not
to do a cervical exam.
07:12
And that's a really
great pause to make.
07:14
Because until we know whether
the membranes are ruptured,
then we want to avoid doing
anything that might increase
the chance of infection,
and a vaginal exam
would absolutely do it.
07:24
So hopefully you were able to put
all of that together
and come up
with a great story for Lee.