00:00
Hi! Welcome to our
video series on HIV.
00:04
Now in this one, we're going to
take a look at the HIV life cycle.
00:07
Whoa Whoa! Stay with me.
00:09
It is more exciting than
it sounds I promise,
because if you've been
around long enough
or if you read the history
HIV used to terrify us.
00:19
We thought it was
a death sentence
but not anymore
and these are the drugs that
have helped us achieve that.
00:27
Now they're not a cure,
but they can extend life
and help people live full
and healthy lives with HIV.
00:34
So let's take a look
at the results of this and
how things work together
because this is really exciting.
00:42
Okay so how does the immune
human immunodeficiency
virus replicate?
Well, here's the bad
news see it goes after
a person's own cells.
00:53
It replicates at the expense
of the CD4 T-cell.
00:57
Now CD4 T-cells
their helper cells,
It's a type of white blood cell.
01:02
It's supposed to defend
the person right?
It's a key component
of the immune system.
01:08
So HIV invades these cells
and talks them into
reprograms them
to replicate the virus HIV.
01:19
That's why it's at the expense
of a person's own CD4 T-cells.
01:25
So let's do a review
of that life cycle
got a great picture
for you there.
01:30
Where you see how HIV
attaches to these cells
because HIV can't grow
or reproduce on its own.
01:38
This is like that roommate
that doesn't pay rent that
you cannot get rid of right?
So HIV cannot grow or
reproduce on its own.
01:47
That's the important thing
for you to keep in mind first.
01:50
So HIV has to attach
itself to a T helper cell.
01:55
Remember that's just
a type of white cell.
01:57
So HIV attaches to the
cell and fuses with it
and takes control
of a body's cell.
02:05
So it attaches to
it it fuses with it
and it takes control
of the cell's DNA.
02:11
So it takes a cell and turns it
against the body that it's in
because HIV replicates
itself inside the cell
and then finally releases
more HIV into the blood
and it just keeps
going on and on and on
so it's making copies of itself,
but it doesn't exist
without a CD4 T helper cell
that it can take over
and hijack and talk it
into creating copies of HIV
to be released into the body.
02:40
So that's even more specific.
02:41
We've got a picture
for you there.
02:43
But you've got the concept
you see it attached.
02:46
You see it fuses with the
cell DNA makes us new RNA
and now it starts making copies.
02:53
This is where
antiretroviral treatment
really helps a patient.
02:58
So this is a range of drugs
that target different stages
in the HIV life cycle.
03:04
So that's why we're going to
break down the different stages
understanding the mechanism
of action of these drugs
is just a simple as recognizing
the stages of the
HIV life cycle.
03:14
So if they take these medications
correctly and consistently
anyone with HIV
needs to understand
as you all Health
Care Providers,
but this treatment is
only as effective as
compliant as they can be
with taking the medication
correctly and consistently.
03:31
It's everyday and
if they can do that,
then it's pretty effective in
keeping the HIV viral count low
and the immune system healthy.
03:40
See the less of this virus
the number viral
load or viral count
in my bloodstream
the healthier my immune
system should be.
03:49
People with healthy immune
systems have fewer symptoms
and less risk of
developing AIDS.
03:56
So that's it.
03:57
That's the goal of
antiretroviral treatment or ART.
04:00
I want to minimize the number
of HIV viruses in
the bloodstream.
04:04
My goal is for the patient
to get to undetectable.
04:08
But even if we can't get it all
the way down to undetectable
we want to get it
as low as possible.
04:14
Now they're one problem with art
is there's an issue
with drug resistance.
04:18
Now, there's a higher
risk of drug resistance
if the patient can't be
consistent with the medication.
04:23
So if they don't take them
the way they're prescribed
and take them consistently
drug resistance can develop.
04:29
Just we're to like
what happens with
not exactly the same mechanisms,
but we teach the same concepts
of people with antibiotics.
04:36
Hey, please take the
full prescription
of the medication
same thing with art
gotta follow the
healthcare providers orders
or directions for
taking the medication.
04:47
Remember the higher
the viral load
the more viruses
able to replicate
and harm the immune system.