00:00
The last subject of this lecture is hemoptysis,
coughing of blood. Now minor hemoptysis as
I discussed in the clinical history lecture
is a common problem, and actually often
irrelevant. However, it could be a warning
sign of somebody who has a severe disease
such as lung cancer and needs to be taken
seriously when it happens for the first time.
00:22
And common causes of this are lung cancer,
lung infection, bronchiectasis, pulmonary
emboli, and actually many patients we are
not sure why they are coughing up blood.
00:30
The point here is that patients who cough out
blood and if they smoke they need a chest
X ray and they'd either need a CT scan or
bronchoscopy to absolutely make sure that there
is no evidence of lung cancer. Major hemoptysis
is a very serious problem. If you cough up
200mls of fresh blood in 24 hours that will put
you at high risk of a life threatening problems.
00:54
Either due to drowning in your own blood or
because of loss of volume of blood. So what
causes major hemoptysis? Largely, it's lung
cancer or tracheal tumours, Bronchiectasis,
Aspergillomas, And tuberculosis, there are
a bunch of rarer causes, but they are very
rare in general. As I've mentioned, the
problem here is that
the loss of blood can cause hypovolemic shock,
but actually more problematic is the
presence of a large amount of fluid in the
airways can cause essentially drowning.
01:28
How do we treat these patients? Well, straightforwardly
- Clear and maintain an airway via suction,
get rid of the blood in the upper airways
as much as you can, so whatever oxygen you
give the patient can get down into the lungs.
High flow oxygen, you put in a large bore
cannula, you take some blood including cross-matching
and clotting, and you give the patient intravenous
fluid replacement and then blood if necessary
depending on how far the hemoglobin forms.
01:55
You need to do some investigations to try
and work out where the source of bleeding
is, chest X ray initially, maybe a CT scan,
a bronchoscopy, and potentially pulmonary
invasive angiography to identify the bleeding
source. An important point is that if you
know which lung is bleeding then you position
that down, you lie the patient, if it’s
a right lung, you lay the patient on the right
side, and that means that any blood that’s
being produced stays in the right lung, and
the good lung, the left, stays clear.
02:24
You have to know where the source of bleeding
is to do that, but it’s an incredibly important
way of preventing the good lung being affected
by the bleeding. We use tranexamic acid to
promote clotting, and if somebody does have
a clotting disorder, then with high INR or
low platelets then you might need to use vitamin
K or platelets respectively. If the patient
has severe and ongoing hemoptysis that is
not settling with the initial therapies then
you need to think about ways of stopping the
bleeding, and there are two main ways of doing
that. One is that you resect the piece of
lung that is bleeding and that is a lifesaving
surgical maneuver. However, to do that you
need to know which bit's bleeding and you
also need to know whether the patient can
cope with their lung function being reduced
afterwards by that resection so if you are
taking out the right upper lobe, that will
reduce the patient’s ability to breathe.
And many of those patients have chronic lung
disease, that makes that not possible to do
because the resection will precipitate the
respiratory failure. The alternative is arterial
embolization. That’s an angiography procedure
where you pass a thin catheter down into the
bleeding vessel which is normally a bronchiole
artery rather than a pulmonary artery, and
embolize it by clogging it off with small
coils and metal, and that clogs off that bleeding
vessel, and slows down and stops the blood
production from that bleeding vessel. And
again, that could be a lifesaving procedure
in patients presenting with major hemoptysis.
So, to summarize the discussion of airways