Helicobacter Pylori Infection

by Carlo Raj, MD

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    Let us now officially move in to <i>H. pylori</i> Remember that <i>H. pylori </i> is associated in both types of peptic ulcer disease. It's a gram−negative, comma−shaped bacillus fecal−oral transmission Prevalence increases with age; 50% infection among the general population greater than 60, extremely common. High prevalence in developing countries, much more so. Risk factors include: low socio−economic status, increased population, institutionalization. And by institutionalization, we mean that we're talking about a patient who might have had psychiatric issues therefore committed. In those closed quarters, pretty sure that you're patient will have <i>H. pylori</i>. Look for such history in your patient. Comma−shaped organism, flagellated. It has urease activity so that it can then take the urea to produce ammonia to protect itself. Serology IgG antibody always remains positive after eradication because this is long−term IgG. Urea Breath Test is important for diagnosis. High sensitivity and specificity; stop the PPI therapy because this then allows for the <i>H. pylori</i> to actually thrive. Biopsy Urease Test Instant result, low cost, but requires gastric tissue. Three major laboratory exams in which you can confirm your <i>H. pylori</i> or confirm the existence of it somewhere in your GI tract. There is a Stool Antigen Test useful for documentation of eradication. Histology Highest sensitivity and specificity Tissue Culture Cumbersome, used however for unfortunately, antibiotic resistance is part of reality. Cumbersome but useful with refractory. The combination antibiotic and anti−secretory agents results in eradication with the high percentage of your patient. And it is that simple to be diligent about getting rid of your <i>H. pylori</i> so that you prevent perhaps cancer from taking place. Metronidazole seems to be increasing with resistance re−infection is always a possibility. Not recommended for asymptomatic patients. Now briefly, just management with antibiotics. Bismuth, Metronidazole, Tetracycline, H2 blockers PPIs, no. We...

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    The lecture Helicobacter Pylori Infection by Carlo Raj, MD is from the course Stomach and Duodenum Diseases.

    Author of lecture Helicobacter Pylori Infection

     Carlo Raj, MD

    Carlo Raj, MD

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    Can be improved
    By Hamed S. on 09. March 2017 for Helicobacter Pylori Infection

    It would would have been good to further elaborate on dx testing and in which clinical circumstances one would be more appropriate over the other. Also with the increasing incidence of resistant organisms I feel the lecture didn't adequately outline appropriate second line management. Also the error regarding PPI which was flagged by another listener