00:01
Hi! Welcome to our video
series on glomerulonephritis.
00:05
Now in this one we're
going to take a look
at goodpasture's syndrome
or anti GBM antibody disease.
00:12
Now the reason it has two names
because it was originally
found by Dr. Good pasture.
00:17
That's why they named
the syndrome after them.
00:19
But anti GBM antibody disease
is actually a better descriptor.
00:24
So sorry, Dr. Good pasture,
but here's what it looks like.
00:28
The NIH are National
Institutive of Health
also lists other names,
look at this like
rapidly Progressive
glomerulonephritis
with pulmonary hemorrhage.
00:38
That's what separates it from just
rapidly progressive glomerulonephritis.
00:42
There's the
pulmonary hemorrhage.
00:44
It's also called the anti
glomerular basement membrane
antibody disease got it.
00:50
Anti GBM antibody disease.
00:53
So it always pass that
make sure you look at that.
00:56
So anti means against
glomerular basement
membrane, so clearly
this is against the glomerular
basement membrane antibody disease.
01:08
Okay?
That's why it's called anti GBM
against glomerular
basement membrane
antibody disease, got it?
I promised much more clear as
we finish this video series.
01:21
The last one,
it's also called glomerulonephritis
and Pulmonary Hemorrhage.
01:27
All right, that is a lot of
names for the same problem.
01:31
What ends up happening is
we have both a pulmonary
involvement with the Hemorrhage
and glomerulonephritis
in the kidneys.
01:38
So goodpasture's syndrome or
as we know the antibody GBM
antibody disease, right?
Same thing.
01:47
Let's look at what
it really does.
01:49
Now goodpasture's syndrome
or that other name that
we just talked about
is a pulmonary renal syndrome
meaning it involves the
lungs and the kidneys,
so it's considered a
pulmonary renal syndrome
because it hits both of those.
02:03
It does damage to
both the kidneys
and to the lungs.
02:07
So glomerulonephritis remember that's
an inflammation of the glomeruli.
02:11
It happens in both kidneys.
02:13
Those glomeruli are
those worker bees.
02:15
They're one of three important
parts of the Nephron.
02:19
The nephron is the
working unit of the kidney
if I've got problems
with my glomerulus,
I've got big problems
overall for my kidney.
02:27
So the kidney is
having problems.
02:29
It's struggling because
because of the inflammation
of the glomeruli.
02:33
So it can be acute
or it can be chronic
and we're talking
about all different
types of glomerulonephritis.
02:39
And remember in this state,
It's one of the major causes
of end stage renal disease,
Now that's we're talking about
glomerulonephritis as a whole
there's lots of different causes
and why the kidneys
get into trouble
or develop glomerulonephritis.
02:55
So we're looking at goodpasture's
syndrome in this one.
02:58
Remember it can be
caused by infections,
Because by autoimmune
disease, vasculitis
things that scar the glomeruli
like diabetes or hypertension
or those weird ones
like amyloidosis that
extra protein that
lodges in the kidneys
or illegal drug use.
03:14
So we're showing you this
slide just to kind of see
where this all fits in.
03:19
We're talking about a really
different a special kind of
pulmonary and renal involvement.
03:25
So this glomerulonephritis
is an autoimmune disease,
so it's called
goodpasture's syndrome.
03:30
You've heard that name but
I want you to recognize
that you might see it in the
literature by any of those names
that we talked about.
03:37
Now it's pretty rare.
03:38
It is an autoimmune disease
means the body turns on itself.
03:42
So the body makes
these antibodies
that attack the collagen
of the basement membranes
in the glomerulus.
03:49
The GBM the glomerulus
basement membrane,
So it hits them
in the glomerulus
and in the alveoli
of your lungs.
03:58
Okay. Now this is where it
gets really really interesting
if it's not happening to your
body, right
but this is fascinating
for it to study.
04:07
We know it doesn't
happen very often.
04:09
It occurs in less than
one in a million people
and it usually hits young
white males aged 15 to 35.
04:17
So that's who you're most likely
to see develop this syndrome.
04:21
But we're thinking about
the basement membranes
in both of the lungs
and the kidneys
they start taking a hit
and that's when things
get really really crazy.
04:32
That's why the two most
defining characteristics
of goodpasture's syndrome
are pulmonary
alveolar Hemorrhage
meaning those of you
I end up bleeding
and when they're bleeding
in filling with fluid,
they can't exchange
CO2 and O2 well,
so they're going to be
difficult to manage there
and they have acute
rapid glomerulonephritis.
04:52
So that means the
kidneys take a big hit
and they take it in
a really fast way.
04:57
So the syndrome can last
for a few weeks to 2 years.
05:01
Can you imagine how that
would impact your life?
So it's rare.
05:07
It happens in less than
one in a million people.
05:10
It's an autoimmune disease,
most commonly affects young
white men aged 15 to 35.
05:17
Now, you're start to think
about goodpasture's syndrome
you're thinking about
it's a pulmonary problem
and a renal problem and it goes
after that basement membrane
and it can last for two weeks
which would be more
than enough for anyone
but up to two years
you're gonna have to
manage these symptoms.